骨科治疗用可注射水凝胶微球的制备方法与性能研究

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中图分类号： TQ427.2+6 文献标志码：A文章编号：1001-5922（2026）03-0630-04

Study on preparation and properties of injectable hydrogel microspheres for orthopaedic therapy

ZHOU Benyu（Shangluo University，Shangluo 726ooO，Shaanxi China）

Abstract：Sodium alginate hasbecome an important material for constructing injectable hydrogel systems due to its abundant natural sources，low cost and excellent biocompatibility.A large number of carboxyl and hydroxyl groups on its molecular chains provideactive sites for chemical modification，andthe gelation time，mechanical strengthand degradation rate can be preciselyregulated through various strategies suchas ionic cross-linking，oxidation-Schiff base reaction，enzyme-catalyzed cros-linking and photoinitiated covalent network construction.Studies have shown thatloading bioactive componentssuch as growth factors，stem cells，antibacterial agents and genevectors into sodiumalginate microspheres can forma three-dimensional bionic microenvironment insituafter injection，whicheffectivelysupportscelladhesion，proliferationand directional diferentiation.Thissystem exhibitsstrongapplicationvalue in the fieldsof cartilage repair，bone defect filing，chronic woundhealing and local sustaineddrug release，and is suitable for minimally invasive interventional therapy scenarios.

Key words ：orthopaedic disease therapy;injectable hydrogel microspheres;preparation method

可注射水凝胶作为再生医学的重要载体材料， 其应用优势在于具有高含水量、类细胞外基质结构、微创递送能力。（剩余5724字）