睡眠质量与气道神经源性炎症指标在“风咳”中的应用研究

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Application of Sleep Quality and Airway Neurogenic Inflammation Indicators in “Wind-cough'

CHEN Juesong'，LI Huiping1，CHEN Daiyun1，FANG Weiye1，ZENG Xiaohui² （1 Department of Internal Medicine，Humen Hospital of Traditional Chinese Medicine，Dongguan 523900， China； 2 Guangzhou Development District Hospital，Guangzhou 510730，China）

AbstractObjective：Toexploretheassociationbetweenslepqualityandairway neurogenic inflammationinthepathogenesisof “wind-cough”intraditionalChinesemedicine.Methods：Atotalof9Opatientsadmitedto Humen HospitalofTraditionalChinese Medicine from October 2023 to October2O25 were enroledand divided into three groupsaccording to experimental requirements： post-coldcough group，thepost-cold non-coughgroupandthe healthycontrol group，with 3Ocasesineach group.Coughreflex sensitivity（CRS） was evaluated by capsaicin provocation test. According to the standard of C2≤1. 95 μ mol/L，the patients were divided ntotheCRSincreased group（19 cases）andthenormal group（71cases）.Sleepqualitywasevaluated byPitsurgh Sleep Quality Index（PSQI），and theexpresion levelsof（SP），calcitonin gene-relatedpeptide（CGRP），nervegrowthfactor （NGF）and brain-derived neurotrophic factor（BDNF）inairway mucosa were detectedbyimmunohistochemistry.Results;The PSQI scoresandtheexpressonofeach neuropeptideinthepost-coldcoughgroup weresignificantlyhigher thanthoseintheother two groups（ P<0.05， . The indicators in the CRS increased group were also significantly higher than those in the normal group （ P<0.05 ）.The PSQI scores and various inflammatory indicators were positively correlated with post-cold cough and CRS（ P< 0.05）.Conclusion;Thedeclineinsleepqualityandtheincreaseinthelevelofairwayneurogenicinflammationarecloselyelated to the onset of“wind-cough”，and both factors are involved in the disease process.

KeywordsWind-cough；Slepquality；Substance P；Calcitoningene-relatedpeptide；Nerve growth factor;Brain-derived neurotrophic factor；Cough reflex sensitivity；Pittsburgh Sleep Quality Index 中图分类号：R338.63;R256.11 文献标识码：A doi：10.3969/j. issn.2095 -7130.2025.10.031

中医“风咳”是一种以阵发性、急迫性呛咳为典型特征的疾病，病机同气道神经源性炎症密切相关[1-2]。（剩余5182字）