瑞马唑仑不同剂量对输尿管镜碎石患者术后睡眠质量的影响

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Effect of Different Doses of Remimazolam on Postoperative Sleep Quality in Patients Undergoing Ureteroscopic Lithotripsy

GENG Minjian

（Beijing Anzhen Hospital Nanchong Hospital/Nanchong Central Hospital，Nanchong 637Ooo，China）

AbstractObjective：ToinvestigatetheefectofdiferentdosesofremimazolamonpostoperativesleepqualityinpatientsundergoingtransurethralureteroscopiclaserithotripsyMethods：Atotalof40patientshouderwenttransurethralureterocopiclaser lithotripsyatBeijingAnzhen HospitalNanchong HospitalfromJanuary2023toDecember2O24 wereselectedandrandomlydivided into a low-dose group（ remimazolam 0.2mg/kg，n=46 ），a medium-dose group（ remimazolam 0.3mg/kg，n=47 ），and a highdose group（ remimazolam 0.4mg/kg，n=47 ）. The Pitsburgh Sleep Quality Index（PSQI） was used to compare postoperative sleepqualityamong the thre groups，andthe Visual Analogue Scale（VAS）was used to assess pain before andafter intervention.Thefirst exhaustime，firstdefecationtime，andbowel soundrecoveryime wererecorded.Theincidenceofcomplications，in cluding diziness，nausea，andhypotension，wasalsocomparedamong groups.Results：After intervention，PSQIandVAscores in the medium-doseandhigh-dose groups were significantlylowerthanthose inthelow-dose group，andthediferences among groups werestatistically significant（ P<0.05 ）.Thebowel sound recovery time，first exhaust time，and first defecation time in the lowdose and medium-dose groups were shorter than those in the high-dose group with statisticalysignificant diferences（ P<0.05） ： Theoverallincidenceof postoperativecomplications inthehigh-dosegroupwassignificantlyhigherthanthatinthemedium-and low-dose groups，and the difference was statistically significant（ P<0.05 ）.Conclusion：A medium dose of remimazolam（O.3 mg/ kg）canefectivelyimprovepostoperativeslepqualityelievepain，shortenrecoverytime，andreducetheincidenceofotoperative complications in patients undergoing transurethral ureteroscopic laser lithotripsy.

KeywordsTransurethralureteroscopic laser lithotripsy；Anesthesia；Remimazolam；Dosage；Sleepquality；Pain；Gastrointestinal function；Complications

中图分类号：R691.4;R338.63 文献标识码：A doi：10.3969/j. issn.2095-7130.2025.10.012

尿路结石是泌尿外科的常见疾病，常伴有剧烈疼痛、泌尿系梗阻及感染，若不及时有效治疗，会引起肾功能损害，严重者甚至导致肾功能衰竭[1-3]。（剩余5537字）