氯硝西泮联合脑电生物反馈对精神分裂症伴睡眠障碍患者的效果

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Effects of Clonazepam Combined with Electroencephalographic Biofeedback onSleep Disorders in Patientswith Schizophrenia

LIN Xiaorong，LI Xuefang

（Xianyue Hospital of Xiamen/Affliated Xianyue Hospital of Xiamen Medical College/Fujian Provincial Mental Health Center/Fujian Clinical Research Center for Mental Illness，Xiamen 36l012，China）

AbstractObjective：Toanalyzetheclinicalvalueofclonazepamcombinedwithelectroencephalographic（EEG）biofeedbackin thetreatmentofschizopheniapatientswithcomorbid sleepdisorders.Methods：Atotalof11Opatientswithschizophreniaand sleepdisorders who weretreatedat Xianyue Hospitalof Xiamen from March 2023 to March 2025wereselectedas studyparticipants.According totherandomnumbertablemethod，theyweredividedintoacontrol groupandanobservationgroup，with55cases ineach.Thecontrolgroupreceivedoral clonazepam treatment，whiletheobservation groupreceivedcombined EEGbiofedback therapy.The Pitsburgh Sleep Quality Index（PSQI）wasused tocompare sleep quality between the two groups.The Athens Insomnia Scale（AIS）wasused to assessimprovements in insomniasymptoms，and the Positiveand Negative Syndrome Scale （PANSS）was used to evaluate changes in psychiatric symptoms.Brain functional status—including brain energy consumption， drowsiness，andbrainfatigue—wasasessedusingamultifunctionalcombined monitorTheincidenceofadversereactions was also comparedbetweenthetwogroups.Results：Before treatment，there werenosignificant diferences betwenthetogroups insleep quality，psychiatric symptoms，or brain function indicators（ P>0.05 ）.After treatment，PSQI and AIS scores in the observation group were significantly lower than those in the control group，indicating better sleep quality（ P<0.05 ）. PANSS scores in the observationgroupweresignificantlylowerthanthoseinthecontrolgroup，andbainenergyconsumption，drowsiness，andbainfatigue scores were also markedly lower（ P<0.05 ）. There was no significant increase in the incidence of adverse reactions between the two groups（ P>0.05 ）. Conclusion： Clonazepam combined with EEG biofeedback therapy can significantly improve sleep quality，allviatepschoticsymptoms，ndehancebraifunctioninpatintswithszopheniandcomorbidsleepdisodes.he treatment demonstrates good tolerability，high safety，and strong clinical applicability.

KeywordsSchizophrenia；Sleep disorders；Clonazepam；Electroencephalographic biofeedback；Sleepquality；Psychiatric symptoms ; Brain function; Adverse reactions

中图分类号：R749.3;R338.63 文献标识码：A doi：10.3969/j. issn. 2095-7130.2025.10.005精神分裂症是一种慢性退行性精神疾病综合 征，表现为感知、思维、情感及认知等多方面的异常，对患者正常生活造成显著影响[1]。（剩余5641字）