帕金森病患者睡眠障碍的评价及其治疗方法

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Evaluation and Treatment Methods of Sleep Disorders in Parkinson's Disease Patients

SHENHaipeng1，GAO Lin1，ZHENG Xiaofen1，GUAN Weixian² DepartmentofEncephalopathy，LongyanHospitalofTraditional Chinese Medicine，Longyan3640o，China;2Department of Acupuncture and Moxibustion，Xiamen Hospital of Traditional Chinese Medicine，Xiamen 361ooo，China）

AbstractObjective：Toexploretheficacyof hierarchicalmanagementscheme inimprovingsleepdisorders inParkinson'sdisease（PD）patients.Methods：Atotalof 8Opatients withPDandsleepdisordersadmitedtothe DepartmentofEncephalopathyat Longyan Hospitalof Traditional ChineseMedicinefrom March2O2 to February2O24 were enroled.Patientsreceiveda1-week stratifiedinterventionconsistingofnonpharmacologicalinterventions（althducation，otothrapy），individualizeddication adjustments[melatonin3-6mg/dayforrapid eye movementsleepbehaviordisorder（RBD）treatmentadjustmentof dopamine receptoragonistdosage toimprove excessivedaytimeslepiness（EDS）]，andsleeprestriction therapy.Subjective sleepqualityand nightime arousalparameters wereassedusingthePitsburgh SleepQualityIndex（PSQI）scaleandactigraphy.ResultsAfter intervention，the total score of PSQI decreased from 15.36 ±3.16 points to 8.17±2.54 points（ t=15.862，P<0.01） . The frequency of nighttime awakenings decreased from 3. 81±0.94 times to 2. 15±0.61 times（ t =7.926， P<0.01 ），and the number of long arousal events（ >5 minutes） decreased from 1.84±0.52 times/night to 0.73±0.23 times/night（ t=6.358，P<0.01） 一Conclusion：Stratified managementcanefectivelyimprove theslpqualityofPDpatients，reduce nightime awakenings，and has significant clinical benefits.

KeywordsParkinson's disease；Sleep disorders；Nightime awakening；Excessve daytime slepiness；Rapid eye movement sleep behavior disorder；Sleep quality；Sleep continuity；Sleep architecture

中图分类号：R338.63；R741.5；R749.9 文献标识码：A doi：10.3969/j.issn.2095-7130.2025.10.011

帕金森病作为神经系统常见退行性疾病，以动作迟缓、肢体震颤、肌肉僵硬及平衡障碍为主要表现[1]。（剩余5603字）