灵芝和肝汤联合疏肝健脾针法治疗失眠的临床研究

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Clinical Study on the Treatment of Insomnia with Liver-calming Lingzhi Decoction Combined with Liver-soothing and Spleen-invigorating Acupuncture

TAOHongyan'，LI Jielian²

（1Humen Hospital of Traditional Chinese Medicine，Guangdong Pharmaceutical University，Dongguan 5239oo，China; 2 SongshanLake High-tech Industrial Development Zone Community Health Service Center，Dongguan 5239o，China）

AbstractObjective：Toobservetheclinical eficacyof Liver-Calming Lingzhi Decoctioncombinedwith liver-soothingand spleen-invigoratingacupunctureinthetreatmentofinsomnia.Methods：Atotalof238patientswith insomia whoweretreatedat Humen Hospitalof TraditionalChineseMedicineFrom January2O23toJanuary2O25，GuangdongPharmaceutical University （treatment periodnotspecified），were enroledasstudyparticipants.According totherandom numbertable method，theyweredividedintoacontrol groupandanobservation group，with119cases ineachgroup.Thecontrolgroupreceivedoralestazolam，while theobservationgroup wastreated with Liver-Calming Lingzhi Decoctioncombined with liver-sothing and spleen-invigoratingacu puncture.Both groups were treated for14 days.The Pitsburgh Sleep Quality Index（PSQI）was used to evaluateslepqualitybeforeand aftertreatment.Enzyme-linkedimmunosorbent assy（ELISA）wasused tomeasureserumlevelsof5-hydroxytryptamine （5-HT）anddopamine（DA）.Treatment eficacywascomparedbetweenthetwogroups.Results：After intervention，thetotaleffectiverateintheobservationgroupwassignificantlyhigherthanthatinthecontrolgroup.PSQIscoresintheobservationgroupwere significantlylowerthanthoseinthecontrolgroup，while5-HTlevelswerehigherandDAlevelswerelowerthanthoseinthecontrol group. The differences between the two groups were statistically significant（ P<0.05 ）. Conclusion：The combination of Liver-CalmingLigzhi Decoctionandliver-sothingandspleen-invigoratigacupunctureisefectiveinimprovingsleepqualityandmoulating neurotransmiterlevels（5-Hand）inpatientswithinsoma.Thistherapyissafe，efective，andworthyofclinicalprootion.

KeywordsInsomnia;；Lingzhi（Ganoderma）； Liver-CalmingLingzhiDecoction；Liver-soothing and splen-invigorating acupuncture；Sleep quality；5-hydroxytryptamine；Dopamine

中图分类号：R256.23；R338.63 文献标识码：A doi：10.3969/j.issn.2095-7130.2025.10.030

失眠是指入睡困难、易醒或早醒，并导致日间疲倦、注意力下降等症状。（剩余5241字）