持续气道正压通气治疗对心力衰竭合并Ⅱ型呼吸衰竭患者的影响

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Effect of Continuous Positive Airway Pressre on Patients with Heart Failure and Type I Respiratory Failure

WANG Jingjing，WANG Xiaocui

（，Taizhou People's Hospital Afliated to Nanjing Medical University，Taizhou 22530o，China）

AbstractObjective：Toexplore the efect ofcontinuous positiveairway pressure（CPAP）onpatients with heartfailure complicated with type I respiratory failure. Methods：A total of 1OO patients with heart failure complicated with type I respiratory failureadmittedtoTaizouPeople'sHospitalafiliatedtoNanjingMedicalUniversityfromJanuary2O22toJanuary2O25wereselected.According todiferenttreatmentmethods，theyweredividedintoanobservationgroup（CPAPtreatment，53cases）andacontrol group（invasivemechanicalventilationtreatment，47cases）Results：Aftertreatment，teapnea-hypopneaindex（AH）left ventricular end-diastolicdiameter（LVED），C-reactive protein（CRP）and interleukin-6（IL-6）levelsintheobservationgroup were lower than those in the control group，while the lowest nocturnal oxygen saturation（ LSaO2 ）and left ventricular ejection fraction（LVEF）were higher than those in the control group（ P<0.05 ）.AHI showed positive correlation with LVED，CRP and IL-6 levels（ P<0.05 ），and negative correlation with LVEF（ P<0.05 ）. Conversely， LSaO2 showed negative correlation with LVED， CRP and IL-6（ P<0.05） ，and positive correlation with LVEF（ P<0.05 ）. Conclusion： CPAP therapy can improve sleep apnea， improve cardiac function and reduce inflammatory factors in patients with heart failure complicated with type I respiratory failure，andsleeprespirationiscloselyrelatedtocardiacfunctionandinflammatorystate，soitisanefectivenon-invasiveherapy.

KeywordsContinuous positive airway pressure； Heart failure; Type I respiratory failure； Sleep apnea； Apnea hypopnea in-dex；Lowest arterial oxygen saturation；Cardiac function； Inflammatory factors

中图分类号：R541 文献标识码：A doi：10.3969/j.issn.2095-7130.2025.10.018

心力衰竭是多种心脏疾病的终末阶段，发病率和死亡率高，严重影响患者生命质量和医疗资源利用[1]。（剩余4662字）