基于子午流注理论的时辰埋豆法对肝硬化患者“睡眠-觉醒”周期及血氨水平的影响

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Effects of the Meridian Flow-guided Chrono-acupoint Bean Embedding Method on the“Sleep-wake Cycleand Blood Ammonia Levelsin Patients with Liver Cirrhosis

QINMei，HUANGYaming，WU Yanzhen

（Department of Gastroenterology，First Affiliated Hospital of Xiamen University，Xiamen36lO09，China）

AbstractObjective：Toexploretheefectsof the“chrono-acupointbeanembedding”method，basedonthetaditionalChiese medicine（TCM）theoryof meridian flow，onimproving“sleep-wake”cycledisturbancesandbloodammonia levelsin patients with livercirhosis.Methods：Atotalof6Opatients with livercirhosis whowereadmitedtothe DepartmentofGastroenterology， FirstAfilatedHospitalofXiamenUniversityfromJauaryO23toDecemberO24wereselectedasstudyparticipantsadandomlydividedintoacontrolgroupndanobservationgroup，with3Ocases ineachgroup.Thecontrol groupreceivedroutinenursingcare，whiletheobservation group wastreated withthechrono-acupointbeanembedding method guided bythe meridianflow theory，inadition toroutinecare.Both groups were treatedforfour weeks.ThePitsburgh SlepQualityIndex（PSQI）wasusedto assesschanges insleepqualitybeforeandafter intervention.Polysomnographywasusedtomonitorslepparameters，including to tal sleeptime，non-rapideye movement（NREM）sleepduration，waketime，sleplatency，numberofawakenings，ndsleepeficiency.Aspectrophotometer was used to measure changes in blood ammonia levels before and after care.Results：After nursing， the PSQI score of the observation group was significantly lower than that of the control group（ P<0.05 ）. After nursing care， the total/non-rapid eye movement sleepdurationand sleeeficiencyoftheobservation groupwere higherthan thoseofthecontrol group，whilethe wake timeand sleeponsetlatencywere shorter，andthe numberof awakenings waslowerthan thoseof thecontrol group （ P<0.05 ）for all comparisons.After nursing care，the blood ammonia level of the observation group was lower than that of the control group（ P<0.05） .Conclusion：The chrono-acupoint bean embedding method based on the TCM meridian flow theorycan efectively improveslepqualityand sleepstructureandreduce bloodammonialevels inpatients withlivercirrhosis， showing potential for broader clinical application.

KeywordsMeridian flow theory；Bean embedding therapy；Liver cirrhosis；Sleep disorder；Biological rhythm；Blood ammo nia ; Polysomnography； Sleep structure

中图分类号： R657.3+1 ;R338.63 文献标识码：A doi：10.3969/j. issn.2095-7130.2025.10.028

肝硬化属于慢性肝病发展至终末期的阶段，该病症在病理层面呈现出肝组织广泛纤维化以及假小叶生成的典型特征，常伴随肝功能减退和门静脉高压。（剩余4671字）