多发性骨髓瘤化疗患者睡眠质量及影响因素调查研究

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关键词多发性骨髓瘤;化疗;睡眠质量;影响因素;焦虑;抑郁;不良反应;匹兹堡睡眠质量指数 nvestigation of Sleep Qualityand Influencing Factors in Patients with Multiple Myeloma Undergoing Chemotherapy

YIN Xijing

（Department of Hematology，Dehong Prefecture People's Hospital，Dehong 67840o，China）

AbstractObjective：To investigate the statusof slepquality in patients with multiple myeloma（MM）undergoingchemotherapy andtoanalyzetheinfluencingfactors.Methods：Atotalof 8O patients withMMwhoreceivedchemotherapyat DehongPrefecture People'sHospitalfromJanuary2O21toDecember2O24 wereenrolled.SleepqualitywasassssedusingthePitsburghSleepQuality Index（PSQI）.Data werecollectedusingageneral informationquestionnaire，theCancerFatigueScale（CFS），andtheHospital Anxietyand Depression Scale（HADS）.Logisticregressonanalysiswasperformed toidentifyfactors associated withsleepquality in MM patients undergoing chemotherapy. Results：Among the 80 patients，45 cases（ 56.25% ）had sleep disorders. PSQI dimension scores in the sleep-disorder group were significantly higher than those in the normal-sleep group（ P<0.05 ）.The incidence of adversereactios，ietyndpreionsellasSorsresigicantlyigheriesp-dsodergropte normal-sleep group （ P<0.05 ）. Multivariate logistic regression analysis showed that adverse reactions （ OR=2.620 ），anxiety （OR =5.167），depression（ OR=3.334 ），and CFS score（ OR=1.244 ）were independent influencing factors of sleep quality in MM patients undergoing chemotherapy（ P<0.05 ）. Conclusion：The incidence of sleep disorders is relatively high in MM patients undergoig chemotheapy.Sleequalityisainlyidependentlyafectedbydversereactiosanietydepresion，ndcance latedfatigue.Earlyscreeningandcomprehensive interventions targeting these factorsarerecommended inclinical practice.

KeywordsMultiple myeloma；Chemotherapy；Sleepquality；Influencing factors；Anxiety；Depression；Adversereactions; Pittsburgh Sleep Quality Index

中图分类号：R733.3；R338.63 文献标识码：A doi：10.3969/j. issn.2095-7130.2025.12.016

多发性骨髓瘤（MultipleMyeloma，MM）作为一种起源于浆细胞的血液系统恶性肿瘤，其治疗现已步入慢病化管理阶段，患者的生命质量愈发受到关注[1-2]。（剩余4958字）