塞来昔布与盐酸乙哌立松对腰椎间盘突出症术后疼痛及睡眠的影响

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键词塞来昔布;盐酸乙哌立松;腰椎间盘突出症;内镜手术;疼痛管理;睡眠质量;药物联合;效果分析

Effects of Celecoxib Combined with Eperisone Hydrochloride on Postoperative Pain andSleep in Patients with LumbarDisc Herniation

ZHOU Runmei，XIAO Zheyi，CHEN Xiaoming

（Afliated Qingyuan Hospitalof Guangzhou Medical University/Qingyuan People's Hospital，Qingyuan 5115oo，China）

AbstractObjective：Toevaluatetheefects ofcelecoxibcombined with eperisone hydrochlorideonpaincontrolandslepqualitymanagementinpatientsafter endoscopicsurgeryforlumbardischerniation.Methods：Atotalof2OO patientswhounderwent endoscopicsurgeryforlumbardischerniationinAfliated QingyuanHospitalofGuangzhou MedicalUniversity（QingyuanPeople' s Hospital）fromJanuary 2O23 to December2024were selectedasthe studysubjects.They wererandomlydividedintoacontrol groupandanobservation groupusing arandom number table method，with OOcasesineachgroup.After5daysof postoperative interventionnintesityleeualityleeplatency，eficiecyroptionofpsleepndiidenceofdeac tions werecomparedbetweenthetwo groups.Results：Fivedaysaftersurgery，theobservationgrouphadlower incisionandlumbar pain VAS scores than the control group，with statistically significant differences（ P<0.05 ）. Sleep quality was higher in the observation group，with statistically significant differences（ P<0.05， ）. Sleep latency was shorter，while sleep efficiency and proportion of deep sleep were higher in the observation group，with statistically significant differences（ P<0.05 ）. There was no statistically significant difference in the incidence of adverse reactions between the two groups（ P>0.05 ）. Conclusion： Celecoxib combined with eperisonehydrochlorideachieves multi-targetanalgesia，significantlyrelieves postoperativepain inpatients undergoingendo scopic surgery forlumbardisc herniation，and continuouslyoptimizes sleepstructure，whichisworthyof clinical promotion.

KeywordsCelecoxib；Eperisonehydrochloride；Lumbardisc herniation；Endoscopic surgery；Pain management；Sleepquali ty; Drug combination; Efficacy analysis

中图分类号：R338.63；R681.5 文献标识码：A doi：10.3969/j.issn.2095-7130.2025.12.015

腰椎间盘突出症（LumbarDiscHerniation，LDH）是慢性腰腿痛的常见原因，临床上以椎间孔镜髓核摘除术等内镜手术为主流干预路径，尽管其创伤小、术后功能恢复速度快，但患者常出现术后腰骶部疼痛并发症，主要与术中软组织创伤、术后神经根水肿及炎症反应等多重机制有关。（剩余5582字）