经颅磁刺激结合右佐匹克隆治疗脑梗死后失眠

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Effect of Transcranial Magnetic Stimulation Combined with Zopiclone on Post-stroke Insomnia

LUO Na

（Department of Neurology，Sanming First Hospital，Sanming 3530oO，China）

AbstractObjective：Toinvestigatetheclinical efectof transcranialmagnetic stimulation（TMS）combinedwithzopicloneon post-strokeinsomnia，nditsimpactonsleepualitynegativeemotions，andfatigue.Methods：Atotalof72patientswithpoststrokeinsomniaadmitedto SanmingFirst HospitalfromDecember2O23toDecember2O24 wereenroledandassignedtoacontrol groupandanobservation groupaccording toadmissonorder，with36cases ineach group.Thecontrol groupreceivedTMSalone，while theobservationgroupreceived TMScombinedwithzopiclone.Sleepquality（Pitsburgh Sleep Quality Index，PSQ1）， negativeemotions（Self-RatingAnxiety Scale，SAS；Self-Rating Depresion Scale，SDS），andfatigue（Fatigue Scale-14，FS-14） werecompared betweenthe twogroups.Results：After treatment，theobservationgrouphadasignificantlylowerPSQI score （ 5.33±1.24 ）than the control group（ 9.05±1.08 ） P<0.05 ）. Post-treatment SAS and SDS scores in the observation group （ 51.46±5.74，54.37±3.17 ） were significantly lower than those in the control group（ 60.33±3.56，60.41±3.20 ）（ P< 0. 05） .FS-14 scores were also lower in the observation group（ 5.66±1.37 ） compared with the control group（ 7.19±1.83 ）（ P< 0.05）.Conclusion：TMScombined withzopicloneinpatientswithpost-strokeinsomniacanefectivelyimprovesleepqualityalleviate negative emotions and fatigue，and demonstrates high clinical application value.

KeywordsTranscranial magnetic stimulation; Zopiclone； Stroke; Sleepquality；Negative emotions；Fatigue;Anxiety; Depression

中图分类号：R749.1;R338.63 文献标识码：A doi：10.3969/j. issn. 2095 -7130.2025.12.007

脑梗死后失眠为常见并发症，据不完全统计，该病的发生率达 20%～56% ，临床表现为入睡困难、睡眠浅易醒、醒后常伴倦怠乏力等，严重影响患者的生命质量[1]。（剩余5339字）