超高效液相色谱-串联质谱技术在动物源性食品兽药多残留检测中的应用与优化

中图分类号：TS207.3 文献标志码：A 文章编号：1674-0270（2025）34-0108-03

Application and Optimization of Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry Technology in the Detection of Multiple Residues in Food and Veterinary Drugs

LYU Lin (Yingkou Food and Drug Inspection and Testing Center, Yingkou 115oO3, China)

Abstract:The widespreadapplicationofveterinarydrugs inlivestockandaquaculture has increased th riskofdrug residues inanimalderivedfoods.Ultra-high performance liquidchromatography-tandemmassspectrometry(UPLC-MS/MS)technology hasbecome the mainstreamtechnologyfordetecting multipleresidues of veterinarydrugs infooddue toits highseparation efciency,sensitivityandselectivity.ThisaticesytematicalyeviewsteapplicationstatusofUPLC-M/Stechologyin the detection ofmultipleresidues of veterinarydrugs infod matrices suchaslivestock and poultrymeat,aquatic products,and dairyproducts.Itanalyskeytechicalbotleneckssuchasmatrixefectsandpretreatmentefciencyinthdetectionprocess, andproposesthicaloptiationrategiesfromtspctsofmplepetreatmentoizationsumentparameterngnd matrix fect elimination,aiming to improve the level ofmulti-residue detectionoffood and veterinary drugs.

Key Words: ultra-high performance liquid chromatography-tandemmassspectrometry;food testing; veterinarydrug multiresidues; matrix effect; method optimization

兽药可预防和治疗动物疾病、促进生长，但不合理使用易在动物源性食品中残留，因此，各国对食品兽药残留制定了严格的限量标准，对数百种兽药的残留限值作出了明确规定。（剩余4795字）