丹参乙醇提取物的安全性评价研究

打开文本图片集

中图分类号：TS210.6 文献标志码：A 文章编号：1674-0270（2025）34-0019-04

Abstract：This studyevaluatesthesafetyofSalvia miltiorhiza ethanolextractedthrough multiple toxicological tests， and the results indicate that it has good food safety.This study aims to evaluate the safety of ethanol extract of Salvia miltiorrhizaand provideatheoreticalbasis forits developmentinfoodand pharmaceutical fields.Aseries of tests were conducted inaccordance with GB 15193.1—2014 "National Food Safety Standard Procedures for Food Safety Toxicological Evaluation"，including the acute toxicity test，Ames test，mousebone marrow polychromatic erythrocyte micronucleus test，mouse sperm malformation test，andrat9O-dayoral toxicitytestto evaluate thesafetyof ethanol extractof in Salvia miltiorhiza.The resultsareas follows.Acute toxicity：The LD5Oof theacute oraltestin mice is >10.0g/kg⋅ bw， which was classified as non-toxic.Genetic toxicity： Ames test， mouse bone marrow polychromatic erythrocyte micronucleus test，and mouse sperm malformation testare all negative.Long-term toxicity：No obvious toxicityisobserved intherat9O-dayoral toxicitytest.Inconclusion，undertheexperimentalconditions，theethanol extract ofSalvia miltiorrhiza isanon-toxicsubstane，andnoacute，subchronicorgenotoxicityisshown，indicating that the test substance has a certain level of safety.

Key Words： ethanol extract ofSalvia miltiorrhiza; long-term toxicity;acute toxicity; genetic toxicity; safety

1材料与方法

丹参作为养生佳品，主要含黄酮类、水溶性酚酸类、醇溶性丹参酮类等成分[1-2]，现已被用于心脑血管、肝炎等疾病治疗。（剩余3847字）