固相萃取净化结合HPLC-MS/MS检测肉及水产品中喹乙醇的应用研究

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中图分类号：TS254 文献标志码：A 文章编号：1674-0270（2025）34-0065-0

Research on the Application of Solid Phase Extraction and Purification Combined with HPLC-MS/MS to Detect Quinoethanol in Meat and Aquatic Products

MA Yuhua (Laboratory of Nonferrous Geology, Jiangxi Provincial Geological Bureau, Ganzhou 341ooo, China)

Abstract: Inorder to establishan eficient detection method forquinoethanol residues in meatandaquatic products, solid phase extraction (SPE) purification combined with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) technology is used to optimize pretreatment and instrument analysis conditions.The results show that quinoethanol is linearly good in the range of 0.5～50.0ng/mL (R =0.999 6),the detectionlimit is （2号 0.3μg/kg ,and the quantitative limit is 1.0μg/kg ; the standard recovery rate of low, medium and high added concentrations is 89.5%~97.2%,relative standard deviation (SRSD)⩽4.1% . In the test of 20 commercial samples,4 of which are detected with quinoethanol (1.8~4.2 |μg/|kg g),all of which do not exceed the standard. This method is sensitive, accurate and stable,and can be used for daily detection of quinoethanol residues in meat and aquatic products.

Key Words: quinoethanol; meat and aquatic products; solid phase extraction; high-performance liquid chromatography-tandem mass spectrometry; residue detection

喹乙醇作为一种人工合成的广谱抗菌促生长剂，被广泛应用于畜禽及水产养殖，但其具有潜在的蓄积毒性和致癌风险，过量残留会危害人体健康。（剩余6272字）