羟醛缩合反应制备高碳数化合物的研究进展

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中图分类号：TQ013.1 文献标志码：A 文章编号：1671-0460（2026）01-0207-04

Abstract： As one of the most important organic reactions for constructing carbon-carbon bonds，aldolcondensation is widelyapplied infinechemicals，agrochemicals，pharmaceuticals，andmaterialsscience.Inthisarticle，theresearch progressin the preparation of high-carbon-number compounds via aldol condensation was systematically reviewed， the reaction mechanism and industrial applications were analyzed as wellas a specific case on the synthesis of methyl isoamyl ketone （MIAK）. The design idea and development prospect ofhomogeneous catalysts， heterogeneous catalysts， especially amine functionalized heterogeneous catalysts were discussed in detail.

Key words：Aldol condensation；Methyl isopentyl ketone; Aminofunctional catalysis;Methyl isobutyl ketone; Multifunctional catalyst

在有机合成中，将小分子转化为结构复杂、功能多样的目标分子，是实现高附加值化学品制备的核心，这一过程高度依赖于能够形成新碳-碳键的偶联反应。（剩余7797字）