抗高血压1类新药—221s（2，9）的纯化工艺

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中图分类号：TQ463；0621.3 文献标志码：A 文章编号：1671-0460（2026）01-0079-05

Abstract：Inordertoobtaintherapid purificationprocessconditions for theantihypertensivedrug221s（2，9），the crude product was preliminarily separated by using the pressured column chromatography method， the rapid column chromatography method with a sintered glassfunnel，and the continuous vacuum column chromatographymethod，and further purification operations were caried out in combination with the recrystallization method.The experimental results showed that when the sample-to-silica gel mass ratio is 1：10，the pressured column chromatography method had a goodseparation degreeandcould achieve acertain purificationefect whencombined with recrystallization.However， its efficiency and purification yield were relatively low. Although the rapid column chromatography method with a sintered glass funnel hadarelativelyhigheficiency，itsseparation effct was notsatisfactoryand the purificationgoal could not beachieved evenaftersubsequentsecondaryrecrystalization.When thesample tosilica gelmass ratio reached 1：12 in the continuous vacuum column chromatography method， the recovery rate could reach 83.5% and the crude separation purity was 93.2% ， and the purification goal could be achieved through only one recrystallization. The purified method after optimization can rapidlyand eficiently purify221s（2，9），laying a solid foundation for the subsequent pilot-scale process research.

Keywords： 221s（2，9） ;Purification;Process; Optimization;Separation;Pharmaceuticals; Crystallization

随着人口结构的变化以及生活习惯的改变，高血压患病率日益增高，高血压给众多患者的健康造成了严重威胁，逐渐演变成了公共卫生问题[1-3]。（剩余7790字）