HS-GC-MS测定食品用洗涤剂中1,4-二嘌烷时标准加入法与内标法的对比分析

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关键词：顶空气相色谱-质谱法；食品洗涤剂； 1,4- 二噁烷；标准加入法；内标法中图分类号：TS201.6 文献标志码：A 文章编号：1674-0270（2026）01-0057-04DOl : 10.16043/j.cnki.cfs.2026.01.015

Comparative Analysis of Standard Addition Method and Internal Standard Method for the Determination of 1,4-Dioxane in Food Contact Detergents by HS-GC-MS

HENGXiaoping,WANGJin, ZHAO Jian,LIU Mi (Shaanxi Provincial Product Quality Supervision and Inspection Institute, Xi'an 71OO48, China)

Abstract: To optimize the detection method of1,4-dioxane in food contact detergents,this paper systematically compares the performance diferences between the standard addition method and the internal standard method in terms of limit of detection (LOD),precision,accuracy,detection efficiencyand operation difficulty,and puts forward he key precautions for the test operation.With blank food contact detergent samples as the matrix,spiked recovery tests are carried out at low,medium and high concentration levels.The results show thatthe average recoveryrate of the standard addition method is 95.1% 2 103.9% ,and the relative standard deviation ( SRSD , n=6) of the measured values is （204号 1.04% （ 3.85% . For the internal standard method, the average recovery rate is 98.9 % 2 104.8% ,and the SRSD (n=6) of the measured values is 0.36% 2 1.06% . The LODs of both methods are lower than 2.5 mg/kg, meeting the requirements of relevant standards.This paper can provide important reference for the method optimization of1,4-dioxane detection, laboratory quality control and the expansion of CMA qualification.

Key Words: headspace gas chromatography-mass spectrometry (HS-GC-MS); food contact detergent; 1,4-dioxane: standard addition method; internal standard method

食品用洗涤剂中1.4-二嘎烷主要来源于表面活性剂（如烷基酚聚氧乙烯醚）生产过程中的副产物[1-3]1.4-二噁烷是国际公认的致癌物，各国均对其残留量设定了严格限量[4-5]。（剩余6085字）