转基因水稻生产药用蛋白的技术突破、安全考量与产业生态构建

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中图分类号：S511.099文献标志码：A

文章编号：1673-6737（2026）01-0020-06

Abstract：Inordertobalancetheproductionqualityandscaleofmedicinal proteinindustry，thetechnologyof producing medicinalproteinbytransgenicricewasbrokenthrough，andtheecological systemof medicinalproteinproductionwas constructedwith thesupport of safety considerations.The combinationof CRISPR-Cas9and TALENgene editing technologywasadoptedtobreakthroughthegeneeditingtechnologyofmedicinalprotein．Throughstablegenetic transformationandsequenceamplificationofmedicinalprotein，theyieldof medicinalproteincanbeincreasedunderthe samerawmaterials.Throughchromatographicpurificationandconcentration，thebreakthroughofpurification technologyof medicinalproteinproducedbytransgenicricewasrealized.Thepurityofmedicinalproteinproducedbytransgenicrice can reach 99.99% ，and the activity and yield of the protein produced exceed 5.5% and 50% respectively. From the aspectsof toxicity，genesafety，impuritycontent，etc.，thesafetymeasurementindexoftransgenicriceinproducing medicinalproteinwassettorealizequantitativeconsiderationoftheproductionsafetyoftransgenicricemedicinal protein. Withthesupportofbreakthrough technologyandsafetyconsiderations，through theintegrationof planting，research and development，productionandsupervision，theecologicalconstructionof pharmaceutical proteinproduction industrycanbe realized，andtheoverallsynergycanbemaintainedaboveO.6，reachingtheexpectedecologicalpeformance，providing support for the efficient production of pharmaceutical proteins.

KeyWord：Geneticallymodifedrice;Riceproduction;Medicinalprotein;Technologicalbreakthroughs;Safetyconsiderations; Construction of industrial ecology

转基因水稻生产药用蛋白技术是通过基因工程手段，将外源药用蛋白基因精准导入水稻基因组，并利用水稻胚乳细胞作为生物反应器，实现药用蛋白的高效表达与规模化生产的技术体系[-2]。（剩余7103字）