恩格列净联合甘精胰岛素治疗血糖控制不佳2型糖尿病的临床效果

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[中图分类号]R587.1 [文献标识码]A [文章编号]1672-4062（2026）03（a）-0094-05

Clinical Effect of Empagliflozin and Insulin Glargine in the Treatment of Type2 DiabetesMellituswith Poorly ControlledBlood Glucose

ZHENGChuncong，YU Junmin

Departmentof Internal Medicine II，Chun'an SecondPeople's Hospital，Hangzhou，Zhejiang，China [Abstract]Objective Toexploretheclinical effectof empagliflozincombinedwith insulin glargineinpatients with poor blood glucose control in type2diabetes melitus （T2DM）.Methods A total of12O patients with T2DM with poor glycemic control treated in the Chun'an Second People's Hospital from April2022 to April 2025 were selected and grouped， The study group （ n =60） treated with empagliflozin combined with insulin glargine，and control group （ n =60） treated with insulin glargine.Observedthe blood glucosecontrol indicators，insulinresistance，pancreatic function，adverse reactions，and blood glucose levelsof the two groups.Results Compared withbefore treatment，thetime within the target range of blood glucose in both groups was prolonged，the index of pancreatic β -cell function increased，and theamplitudeof blood glucose fluctuation decreased，the study group was superior to the controlgroup，andthediferences were statistically significant （all P <0.05）.Compared with before treatment，the insulin resistance index，fasting insulin，fasting plasmaglucose，2-hour postprandial plasma glucose，and glycated hemoglobin Alc inboth groupsdecreased，andcompared with thecontrol group，the studygroup was lower inalloftheseindicators，andthediffrences were statistically significant （all P <0.05）.There was no statistically significant difference in the incidence of adverse reactions between the two groups （ P>0.05 ）. The rate of achieving blood glucose targets in the study group was higher than that in the control group，and the difference was statistically significant （ P <0.05）. Conclusion Empagliflozin combined with insulinglarginecan improve blood glucosecontrol inpatients withpoorlycontroled T2DM.Itcanpromote therecovery of pancreatic function，alleviate insulin resistance，increase therateofachieving blood glucose targets， optimize the effect of blood sugar control，and hashigh safety.

2型糖尿病（type2diabetesmellitus，T2DM）的病程进展具有长期性和复杂性的特点，随着疾病演变，单纯依赖生活方式干预及口服降糖药物的治疗效果逐渐减弱，部分患者即便在规范治疗下仍难以实现持续、稳定的血糖达标。（剩余5316字）