非布司他与达格列净联合治疗糖尿病周围神经病变伴高尿酸血症的临床应用价值

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[中图分类号]R587 [文献标识码]A [文章编号]1672-4062（2026）01（b）-0187-04

Clinical Application Value of Febuxostat Combined with Dapagliflozin in the Treatment of Diabetic Peripheral Neuropathy with Hyperuricemia

JINWeizhong，ZHANGLi Ezhou Chengnan Hospital，Ezhou 436Ooo，Hubei， China

[Abstract]ObjectiveToanalyzetheclinicalapplication valueoffebuxostatcombined with dapagliflozin inthe treatmentof diabeticperipheral neuropathy with hyperuricemia.Methods110 patients with diabetic peripheralneuropathy andhyperuricemia admited to Ezhou Chengnan Hospital from January to August 2O25 wereconvenientlyselected and divided into two groups according to different treatment methods，with 55 cases in each group.The control group was treated with routinetreatment，and the study group was treated withdapagliflozinand febuxostatonthe basis of routine treatment.Theblood glucoselevel，renal function，neurological functionandadversereactions were comparedbetweenthe two groups.ResultsAfter treatment，the fasting blood glucose of the study group was （4.36±O.48）mmol/L， andthe 2-hour postprandial blood glucose was （5.53±0.61） mmol/L，which were lower than （6.38±0.32） mmol/L， （8.38±0.85）mmol/Lof thecontrol group，andthediferences were statistically significant （t=25.968，20.202;all P< （204号 0.05）.Aftertreatment，the levels of serum creatinine，24-hoururine proteinandurea nitrogen inthe study group were better than those in the control group，and the differences were statistically significant （all P <0.05）.After treatment， the levels of neuropeptide Yand homocysteine in the study group were lower than those in the control group，and the differenceswere statisticallysignificant （all P <0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（ P>0.05 ）.Conclusion The combination of febuxostat and dapagliflozin in patients withdiabeticperipheral neuropathyand hyperuricemiacanreduce their blood glucose levels，improverenalfunction， improve neurological function， and can′t increase incidence of adverse drug reactions.

[Keywords] Febuxostat; Dapagliflozin; Neurological function; Kidney function; Blood glucose level

糖尿病周围神经病变与高尿酸血症是糖尿病代谢综合征常见合并症，二者共存可增加患者心血管事件[。（剩余4364字）