糖尿病患者糖化血红蛋白及血清C肽联合检测的灵敏度及特异度分析

打开文本图片集

[中图分类号]R587.1 [文献标识码]A [文章编号]1672-4062（2026）01（b）-0094-04

Analysis of Sensitivity and Specificity in Combined Detection of Glycated Hemoglobin A1c and Serum C-peptide in Patients with Diabetes Mellitus

HE Kexiang， WANG Jinsheng

DepartmentofLaboratory，Pu'an County People's Hospital， Guizhou，Qianxinan 5615Oo，Guizhou，China [Abstract] Objective To investigate thesensitivityand specificityofcombineddetectionof glycated hemoglobinAlc （HbA1c）and serum C-peptide inthe diagnosisof diabetes melitus （DM）.Methods From January 2024 to February 2025，128 patients with suspected DM were convenientlyselected from Pu'an County People's Hospital.76 patients with confirmed diabetes were selectedasDM group，and 52 non-diabetic patients wereselected as normal control （NC）group.HbAlc and serum C-peptide were detected and compared between the two groups，and the receiver operatingcharacteristic curve was drawn.The diagnostic sensitivityand specificityof the two indexes alone and combined detection for DM were compared.Results The levels of HbAlc and serum C-peptide in the DM group were higher than those in the NC group，and the differences were statistically significant （all P<0.05 ）. The area under the curve of combined detectionof HbAlcand serum C-peptidein thediagnosisofDMwas O.948，andthediagnostic effcacy was better than that of single detection.The diagnostic sensitivity and specificity were 93.42% and 92.31% ，respectively， which were higher than thoseof single detection.Conclusion Thecombined detectionof HbA1candserum Cpeptide in the diagnosis of DMcan improve thesensitivityand specificity，and theoperation process is simple，which is suitable for early screening and diagnosis of DM.

[Keywords] Diabetes melitus; Diagnosis; Glycated hemoglobin Alc; C-peptide;Sensitivity;Specificity

糖尿病（diabetesmellitus，DM）是一种以持续性血糖异常升高为主要特征的慢性疾病，早期往往无明显症状或症状较轻，随着病程延长可能引起眼、肾脏、神经、心血管等组织、器官慢性进行性病变，重则可能导致功能衰竭，或诱发急性严重代谢紊乱而增加死亡风险[]。（剩余4957字）