阿卡波糖联合二甲双胍及门冬30胰岛素治疗2型糖尿病的有效性及安全性

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[中图分类号]R587.1 [文献标识码]A [文章编号]1672-4062（2026）02（b）-0098-04

Efficacy and Safety of Acarbose Combined with Metformin and Insulin Aspart3Oin the Treatmentof Type2Diabetes

FUWeiwei

DepartmentofEndocrinology，theThirdPeople'sHospitalofZhenjiangCity，Zhenjiang212Ooo，Jiangsu，China [Abstract]Objective To studytheefcacyof acarbosecombined with metforminand insulinaspart 3Oin the treatmentof type2diabetes.MethodsAtotalof 6Opatients with type2diabetesadmited tothe ThirdPeople's Hospital of Zhenjiang City from January 2O2Oto May 2025 were conveniently selectedand divided into observation groupand control group according to diferent treatment methods，with3O cases ineach group.The control group was treated with metforminand insulin aspart 3O，whiletheobservation group was treated withacarbose on the basisofthecontrol group.Thetherapeutic efect，blood glucoselevel，isletfunctionand adverse reactions were compared between the two groups.Results The total effctiverate of the observation group was higherthanthatofthe control group，compared withthecontrol groupaftertreatment，thelevelsofglycatedhemoglobinAlc，fasting plasma glucoseand2-hourpos prandial plasma glucose in the observation group were lower，FINS and HOMA-IR were lower，HOMA- β was higher， and the differenceswere statistically significant （all P<0.05 ）.There was no significant difference in the incidence of adverse reactions between the two groups（ P >0.05）.Conclusion In the treatment of type2 diabetes，the combination of acarbose，metforminand insulin aspart3O hasbeter eficacy，which canoptimize theblood glucose controlof patients，improve isletfunction，and has good safetyand willnot significantly increase adverse reactions.

[Keywords] Type2 diabetes;Acarbose;Metformin; Insulin aspart 3O; Safety

2型糖尿病与遗传基因息息相关，具有明显的家族聚集性，部分基因异变影响胰岛β细胞功能及血糖代谢，血糖异常升高[。（剩余5920字）