甘精胰岛素联合门冬胰岛素及盐酸二甲双胍治疗2型糖尿病的效果

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[中图分类号]R587 [文献标识码]A [文章编号]1672-4062（2026）02（b）-0094-04

Effect of Glargine Insulin Combined with Insulin Aspart and Metformin Hydrochloride in the Treatmentof Type2DiabetesMellitus

LIUYuanyuan，HUAXuhong，TANGYichun Department of Internal Medicine，Zhongxing Hospital， Suqian 2236Oo， Jiangsu，China [Abstract]Objective To investigate theefficacyof glargine insulincombined withaspart insulinand metforminhydrochloride in treating type 2diabetes mellitus.Methods 6 patients with type2diabetes melltusadmited to Shuyang Zhongxing HospitalfromJuly 2O24 to August 2O25 wereconvenient selectedand grouped acording todiferences in treatment methods. The control group （ n =33）was treated with insulin aspart+metforminhydrochloride，and the observation group （ n =33） was treated with glargine insulin.The blood glucose level，lipid metabolism and islet function were compared between the two groups，and the adverse reactions of the two groups were counted.Results After treatment，the levelsoffastingplasmaglucose，2-hour postprandial plasma glucose，and glycated hemoglobinAlc，total cholesterol，triglycerideand low density lipoproteincholesterol were lowerthanthoseof thecontrol group，and the highdensity lipoproteincholesterolwas higher thanthatofthecontrol group，thediferences were statisticallsignificant （all P <0.05）.After treatment，the fasting insulin resistance index of the observation group was lower than that of the control group，and the islet β cell function index was higher than that of the control group，the differences were statistically significant （all P<0.05 ）. The incidence of adverse reactions in the observation group were lower than those in the control group，and the difference was statistically significant （ P <0.05）. Conclusion The combination of glargine insulin，aspart insulin，and metformin hydrochloride demonstratesdefiniteeficacy intype2diabetes melitus management，effectively improving glucose and lipid metabolismas wellas islet function，with favorablesafety profiles. [Keywords] Glargine insulin; Aspart insulin; Metformin hydrochloride;Type2 diabetes mellitus; Islet function

2型糖尿病（type2diabetesmellitus，T2DM）属于慢性代谢性疾病范畴，核心病理机制表现为胰岛素抵抗与胰岛β细胞功能渐进性衰退，目前其患病率持续攀升，已成为全球重大公共卫生问题之一。（剩余4908字）