血清BUN、CysC联合CREA在糖尿病肾病中的诊断效能分析

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[中图分类号]R587.1 [文献标识码]A [文章编号]1672-4062（2026）02（b）-0052-04

Diagnostic Efficacy Analysis of Serum BUN，Cystatin C Combined with CREA in Diabetic Nephropathy

XINGCheng，ZHANGJing，GUO Quanbin

DepartmentofLaboratory，Zhongwei People'sHospital，Zhongwei 755，Ningxia HuiAutonomous Region，China [Abstract]Objective To investigate the diagnostic eficacyofblood urea nitrogen （BUN），cystatin C（CysC）combined with serum creatinine （CREA）in diabeticnephropathy （DN）.MethodsA total of 2OO patients with DNadmitted to Zhongwei People's Hospital from January to December 2024 were selected asthe observation group，and 183 patients with simple diabetes at the same time were selected as the control group.The two groups were tested for BUN，CysC and CREA，respectively.Thediffrences inthe levelsof each index between the two groups werecompared，and he diagnosticeficacyof single index combined with three indexes forDNwas analyzed.Results Thelevelsof BUN， CysCandCREAintheobservation group were higher thanthose inthecontrol group，andthediferences were statistically significant （all P <0.05）.The sensitivity，accuracy， positive predictive value and negative predictive value of combined detection were higher than those of single index detection，the differences were statisticallsignificant （all P< 0.05）.Conclusion Thedetectionof serum BUN，CysC combined with CREA can significantly improve thediagnostic effciencyofDN，especiallyintermsofsensitivityandaccuracy，whichcanprovideareliablebasisfortheearlydiagnosis of clinical DN.

[Keywords] Diabetic nephropathy; Urea nitrogen; Cystatin C; Creatinine; Diagnostic performance

糖尿病肾病（diabeticnephropathy，DN）作为2型糖尿病最主要的微血管并发症，其发病率随糖尿病患病群体扩大呈逐年攀升趋势，该病早期缺乏典型临床症状，多数患者确诊时已出现不可逆的肾功能损伤，最终可能发展为终末期肾病，不仅严重影响患者生活质量，还大幅增加医疗负担[1]。（剩余4745字）