对比二甲双胍联合恩格列净治疗2型糖尿病伴肥胖患者的血糖控制与体型管理的效果

打开文本图片集

[中图分类号]R587 [文献标识码]A [文章编号]1672-4062（2026）02（b）-0060-04

Comparing the Effects of Metformin Combined with Empagliflozin in Controlling Blood Sugar and Managing Body Weight in Patients with Type 2 Diabetes Mellitus and Obesity

WANGZhuying，SHIBin，CHENXue

DepartmentofEndocrinology，LongyanPeople'sHospitalofFujian，Longyan364Ooo，Fujian，China [Abstract]ObjectiveTocomparetheeffectsof metformincombinedwithempagliflozinincontrollingbloodglucose and managing body weight inpatients with type2diabetes melitusandobesity.Methods Atotalof 1OO patients with type2diabetes melitus and obesitywho visited theDepartmentofEndocrinologyofLongyan People's Hospitalof Fujian fromJanuary 2O24 to June 2025 wereselected.The patients were divided intothe control group（5Ocases，treated with metformin）andthestudygroup（50cases，treated withmetformincombined with empagliflozin）according todifferenttreatmentregimens.Theblood glucose，lipidlevels，body weightmanagement status，and incidenceofadversereactions wererecorded inboth groups.Results Compared with the control group，the glycated hemoglobinAlc，fasting plasmaglucose，2-ourpostprandial plasmaglucose，low-densitylipoproteinchoesterol，triglycerides，totalcholesterol，bodymassindex，and waist-to-hipratio indicators inthestudygroupwerelowerafter treatmentcompletion，and thehigh-density lipoproteincholesterollevel was higher，thedifferences were statisticallysignificant （all P <0.05）. There was no statistically significant diference in the total incidence of adverse reactions between the two groups （ P >0.05）. Conclusion Compared withtheuseof metformin alone，the treatment regimenof metformin combined with empagliflozin for patients with type2diabetesmelitusandobesitycan achieve more satisfactorytherapeutic effcts，helpcontrol blod glucose and lipid levels，facilitate body weight management，and does notincrease the risk ofadverse reactions.

[KeyWords] Metformin;Empagliflozin; Type2 diabetes melitus; Obesity; Blood glucose control; Body shape manage ment;Effectiveness

2型糖尿病（type2diabetesmellitus，T2DM）作为全球性公共卫生问题，其患病率伴随肥胖率的攀升而显著增加]。（剩余4368字）