清热降浊方联合西格列汀、二甲双孤治疗T2DM伴超重患者的效果

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[中图分类号]R587.1 [文献标识码]A [文章编号]1672-4062（2026）02（b）-0010-04

The Effect of Qingre Jiangzhuo Formula Combined with Sitagliptin， Metformin in the Treatment of Patients with T2DM， Overweight

LIUFutian，LIUin

DepartmentofEndocrinology，Kunshan TraditionalChineseMedicineHospital，Kunshan153oo，Jiangsu，China [Abstract] Objective To analyze theefectof Qingre Jiangzhuo Formula combinedwith sitagliptinand metformin in thetreatmentof type2diabetes melitus （T2DM） patients withoverweight.Methods Atotalof16O patientswith T2DMand overweightdiagnosedandtreated in Kunshan Traditional Chinese Medicine Hospitalfrom October 2023 to October 2025 were selected.According todiffrent treatment methods，the patients were divided into controlgroup（sitagliptin+metformin treatment）and study group（Qingre JiangzhuoFormulacombined with sitagliptin+metformin treatment），with 8Ocases ineachgroup.The levelsof glucose and lipid metabolism，isletfunction，anthropometric indexes and adipokines，and adverse reactions were compared between the two groups.Results Compared with the control group，the fasting plasma glucose，2-hour postprandial plasma glucose，glycated hemoglobinAlc，totalcholesterol，triglyceride，lowdensity lipoproteinholesterol，bodymass index，waistcircumference，leptin，fasting insulinandinsulin resistance index inthestudygroupwerelower，whilehighdensitylipoproteincholesterolandadiponectinwere higher， and the differences were statistically significant （all P<0.05 ）.The total incidence of adverse reactions in the study group was slightly higherthan thatinthecontrol group，and there wasnosignificantdiferencebetweenthe two groups C P>0.05 ）.Conclusion Qingre Jiangzhuo Formula combined with sitagliptinand metformin in the treatmentof T2DM patients withoverweightcanhelpcontroltheblood glucoselevel，improvethe blood lipidlevel，anthropometricindex， adipokines and islet function，and has high safety.

[Keywords]Qingre Jiangzhuo Formula; Sitagliptin; Metformin; Type2diabetes melitus; Overweight;Effect

2型糖尿病（type2diabetesmellitus，T2DM）作为全球性公共卫生挑战，其患病率随肥胖流行呈显著上升趋势[1]。（剩余4656字）