二甲双肌联合恩格列净治疗2型糖尿病合并肾结石患者的疗效

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[中图分类号]R587 [文献标识码]A [文章编号]1672-4062（2026）02（b）-0083-04

Efficacy of Metformin Combined with Empagliflozin in the Treatment of Patients with Type 2 DiabetesMellitus Complicated with Renal Calculi

ZHENGHaichao，LIUongmei，FANGXingshan JingshanRenheHospital，Jingshan4318OO，Hubei，China

[Abstract]ObjectiveTo investigate theclinical eficacyof metformin combined with empagliflozin inthe treatmentof type 2 diabetes melltus （T2DM） with renalcalculi and its effecton blood glucoseandrenal function.Methods From January2023 toApril2O25，104 patients withT2DMcomplicatedwithrenalcalculiadmited to JingshanRenhe Hospital were selectedand groupedbydiferenttreatment methods，with52cases ineach group.Both groups received routinebasic treatment.Thecontrol group was treated with metformin，andthe studygroup was treated with metformin combined with empagliflozin.The blood glucose index，renal function index and incidence of adverse reactions were compared between thetwo groups before and after treatment.Results After treatment，thelevels offasting plasma glucose，2-hour postprandial plasma glucoseand glycated hemoglobinAlc in the study group were lower than those in the control group，and the differences were statistically significant （all P<0.05 ）.There was no significant difference in serum creatinine and estimated glomerular filtration rate between the two groups （all P>0.05 ）.After treatment，the albumin-to-creatinineratioofthestudy group waslower than thatofthecontrol group，and thedifference was statisticallysignificant （ P <0.05）.The total incidence of adverse reactions in the study group was not statistically different from that in the control group （P>O.05）.Conclusion The hypoglycemic efect of metformin combined with empagliflozininthetreatmentof T2DMpatients withrenalcalculiisbeterthanthatofmetforminalone，and itcanbeter improve urinary microalbumin excretion with good safety.

[Keywords]Type2diabetesmellitus;Renalalculi;Metformin;Empagliflozin;Bloodgucosecontrol;Renalfunction

2型糖尿病（type2diabetesmellitus，T2DM）是临床高发的代谢性疾病，随着病程进展易并发肾脏损伤、结石等并发症[1。（剩余5006字）