肥胖相关糖尿病中脂肪一胰岛轴信号通路异常的研究进展综述

[中图分类号]R587.1 [文献标识码]A [文章编号]1672-4062(2026)01(a)-0195-04

Review of Research Advances on Abnormalities in the Adipose-islet Axis Signaling Pathway in Obesity-related Diabetes

LILibin,CAOengyu,LANGYiyao Beijing Tongzhou District Second Hospital,Beijing1O11O2, China [Abstract] Obesity-related diabetes,primarilytype2diabetes,exhibits arising incidencerateannuallyand hasbecome a significant challenge in global public health.Abnormalities in the adipose-pancreatic axis signaling pathway playapivotal role in theonsetand progressionof this disease.Thisreview examines thephysiologicalregulatory basis of theadipose-isletaxis,describes pathological alterations such asdysregulatedadipokinescretion,inflammatoryresponses,andoxidative stresstriggered byadipose tisse dysfunction in obesity,and analyzes the molecular mechanismsby which abnormalities in key signaling pathways of this axis induce pancreatic β -cell dysfunctionand insulin resistance.It summarizes recent experimental and clinical research advances while evaluating potential therapeutic strategies targeting theadipose-isletaxis.This review aims toprovide theoretical guidance for basicresearch and clinical interventionsin obesity-related diabetes.

[Keywords]Obesity;Type2diabetes melitus; Adipose-islet axis;Signaling pathways; Adipokines; Insulinresistance

全球范围内，肥胖和糖尿病的发病率持续上升，肥胖通过诱导代谢紊乱，如胰岛素抵抗和胰岛β细胞功能障碍，推动糖尿病发展。（剩余9803字）