2型糖尿病患者行甘精胰岛素与二甲双胍治疗的疗效及其对血糖及胰岛功能的影响

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[中图分类号]R587.1 [文献标识码]A [文章编号]1672-4062（2026）01（a）-0112-04

The Efficacy of Insulin Glargine and Metformin Treatment in Patients with Type 2 Diabetes and Its Influence on Blood Glucose and Pancreatic Islet Function

'， ²， Defang？

1.DepartmentofEmergency，hangri-LaPeople'sHospital，Shangri-La 6744Oo，Yunnan，China;2.Departmentof Pharmacy，Lijiang WomenandChildren'sHospital，Lijiang 674Oo，Yunnan，China;3.DepartmentofEmergency，econd AffiliatedHospital ofKunming Medical University，Kunming 65oooo，Yunnan，China

[Abstract]Objective To exploretheclinical eficacyof insulin glargineand metformin inpatientswith type2diabetes melltus （T2DM）.Methods It was convenient to select12O patients with T2DM who were admited to Shangri-La People's Hospital from May 2O23 to May 2O25.They were divided into the conventional group and the research group according to diffrent treatment plans，with 6O cases in each group.Theconventional group was treated with metformin，and the study group was treatedwith insulin glargineonthis basis.The pancreatic function，blood glucose indicators，clinical eficacy and adverse reactions of the two groups of patients were compared.Results Compared with the conventional group after treatment，the early-phase insulin secretion index，pancreatic β- cell function index，and totalclinicaltreatment efectiverateof thestudy group werehigher，whilethe insulinresistance index，glycated hemoglobin Alc，2-hour postprandial plasma glucose，fasting plasma glucose levels，and total incidence of adverse reactions were lower， the differences were statistically significant （all P<0.05 ）.Conclusion In the treatment of T2DM，using insulin glarginecombined with metforminhas better eficacywhichcanefectivelycontrolblood glucose，reduce insulin resistance，enhance pancreatic β -cell function and early-phase insulin secretion，and reduce the incidence of adverse reactions.

[Keywords] Type2diabetes melitus; Insulin glargine; Metformin; Isletfunction; Insulin resistance; Blood glucose control

2型糖尿病（type2diabetesmellitus，T2DM）是一种慢性代谢疾病，其特征为胰岛素抵抗伴随胰岛素分泌功能逐渐减退，胰岛β细胞功能代偿性减退，最终导致血糖稳态失衡[1-2]。（剩余5645字）