血清C肽与糖化血红蛋白联合检验在糖尿病诊断中的作用

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[中图分类号]R446 [文献标识码]A [文章编号]1672-4062（2026）01（a）-0069-04

Role of Combined Detection of Serum C-peptide and Glycated HemoglobinA1cin theDiagnosisofDiabetesMellitus

LIXiaofeng，LIShufang，YOUZongtao Department of Clinical Laboratory， Zhangping Hospital， Zhangping 3644Oo， Fujian，China [Abstract] Objective To analyze theroleof combined detection of serum C-peptideand glycated hemoglobin Alc in thediagnosisof diabetes melitus.Methods A total of118 patients with suspecteddiabetes melitusadmitted to Zhangping Hospital from January 2024 to May 2025 were conveniently selected asresearch subjects.Allpatients underwentserum C-peptide detection，glycated hemoglobin Alc detection and oral glucose tolerance test （OGTT）.Taking the resultsofOGTTasthegold standard，the test effctand diagnosticeficacy were statisticallyanalyzed.Results Oral glucose tolerance test was detected in 64 cases positive and 54 cases negative.There were 41 true positive cases of serum C-peptidedetection，43 true positivecasesof glycated hemoglobinA1c detection，and 63 true positive cases of combined detection.Thediagnostic eficacy of combined detectionof serum C-peptide and glycated hemoglobin Alc were higher than those of single detection，and the diferences were statistically significant （all P <0.05）. Conclusion The sensitivity，specificityand accuracyof combined detection of serum C-peptide and glycated hemoglobinAlcarehigherthanthoseof singledetection，which canbeusedasanimportantauxiliarydetectionmethod for early diagnosis and disease classification of diabetes mellitus.

[Keywords] Serum C-peptide; Glycated hemoglobin A1c; Diabetes mellitus; Oral glucose tolerance test

糖尿病的危害不仅局限于血糖升高本身，其引发的微血管病变与大血管病变已成为导致患者残疾及病死的主要原因[1-2]。（剩余4888字）