高血压合并2型糖尿病患者心血管事件风险与血糖变异性关联的回顾性队列研究

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[中图分类号]R587.1；R544.1 [文献标识码]A [文章编号]1672-4062（2026）01（a）-0051-05

A Retrospective Cohort Study on the Association between Cardiovascular Event Risk and Blood Glucose Variability in Patients with Hypertension andType2DiabetesMellitus

XULianl，DENGZhaomei²

1.DepartmentofCardiology，theFirstAfiliatedHospitalofGuizhouUniversityofTraditional Chinese Medicine，Guiyang 50001，Guizhou，China;2.DepartmentofUtrasound Medicine，theFirstAffiliated Hospitalof Guizhou Universityof Traditional Chinese Medicine，Guiyang 55ooo1，Guizhou，China

[Abstract]ObjectiveTo explore therelationship between glycemic variabilityandtheriskofcardiovascular events in patients with hypertension and type 2 diabetes melitus.Methods Aretrospective cohort study design wasused to analyzetheclinical dataof12O patientswith hypertensionand type2 diabetes melitus who were treated in theFirstAffiliated Hospitalof Guizhou Universityof Traditional Chinese Medicine fromJanuary2023 to January2025.The follw-up time was24 months.According to whether major adverse cardiovascular events （MACE）ocurredduring the follw-up period，they were divided into MACE group （32 cases）and non-MACE group （88 cases）.Fasting plasma glucose-standard deviation （FPG-SD）and fasting plasma glucose-coeffcient variation （FPG-CV）were compared betweenthe two groups，and multivariate Cox regression was used to analyze the risk factors of cardiovascular events. Results The FPG-SDand FPG-CV inthe MACE group were higher than those inthe non-MACE group，thediferences were statistically significant （all P<0.001 ）.Kaplan-Meier analysis showed that the high mutation group had a lower MACE-free survival rate，and the difference was statistically significant （Log-rank P =0.004）. Glycemiavariability （FPG-CV ≥17.45% ） was an independent risk factor for MACE in patients with hypertension and type 2 diabetes mellitus （HR=1.821， 95%CI： 1.198-2.769， P=0.005 ）.Conclusion In patientswith hypertension and type 2 diabetes melitus，glycemia variabilityand increasedriskofcardiovasculareventsareindependentrisk factors，suggesting hat blood glucosevariability may be one of the predictors of cardiovascular prognosis.In clinical management，attention should be paid to the average blood glucose level and fluctuation control at the same time.

[Keywords] Hypertension; Type2diabetes melitus; Blood glucose variability; Cardiovascular events

高血压与2型糖尿病是全球最常见的慢性非传染性疾病，在病理生理机制上相互影响[1-2]。（剩余5056字）