自身抗体及生化指标在成人隐匿性自身免疫性糖尿病与2型糖尿病中的诊断价值

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[中图分类号]R587.1 [文献标识码]A [文章编号]1672-4062（2026）01（a）-0072-05

Diagnostic Value of Autoantibodies and Biochemical Indicators in Latent AutoimmuneDiabetesin Adultsand Type 2DiabetesMellitus

HUDanyun，WANGXiao，LIU Jinxiang，XIEJun Department of Laboratory Medicine，Xuyi County People's Hospital，Huai'an 2117OO，Jiangsu， China [Abstract]Objective To explore theapplicationof autoantibodiesand biochemical indicators inthediagnosisoflatentautoimmunediabetes and type2diabetes melitusinadults.Methods A totalof 5Oadult patients withlatentautoimmune diabetesand 5O patientswith type2 diabetes melituswho were diagnosed and treated in Xuyi County People'sHospitalfrom January to December 2O24 wereconvenientlyselected.Allof them were examinedby blood sampling，andtheautoantibodiesand biochemical indexes were measured.The diagnosticeficacyof singleand combined detectionof autoantibodies wascalculated，and the biochemical indexes of the two groups were compared. Results The numberof confirmed cases ofcombined detectionof autoantibodies was more than thatof single detection of autoantibodies.The sensitivity，specificityand accuracyofcombined detection ofautoantibodies were higher than those of single detection of autoantibodies，and the differences were statistically significant （all P <0.05）. The levels of fasting plasma glucose，2-hour postprandial plasma glucose，glycated hemoglobin Alcand low-density lipoprotein cholesterol inadult patientswith latent autoimmune diabetes were higherthanthoseinpatients with type 2 diabetes melltus，andthelevelsof fasting C-peptide，2-hour postprandial C-peptideand high-density lipoproteincholesterol were lower than those in patients with type2diabetes melitus，the diferences were statistically significant （all P< 0.05）.There wereno significant diferences in total cholesterolandtriglyceride levels betweenthe two groups（all P> 0.05）.Conclusion In adult patients with latent autoimmune diabetes and type 2diabetes melitus，combined detection of autoantibodiesand biochemical indicatorscan beused asabasis for differential diagnosis of diseases.

[KeyWords]Adultlatentautoimmunediabetes;Type2diabetesmelitus;Autoantibodies;Biochemical indicators

成人隐匿性自身免疫性糖尿病、2型糖尿病均属于糖尿病，两种疾病在发病机制、临床特征上存在一定差异，前者本质上是缓慢进展的1型糖尿病，是自身免疫性疾病，发病机制是人体的免疫系统对胰岛β细胞发起自身免疫攻击，造成其功能缓慢减退，导致胰岛素分泌不足。（剩余5176字）