5-甲氧基色胺的合成工艺

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引用格式：.5-甲氧基色胺的合成工艺[J].当代化工，2026,55（4）：829-832.

XU Yuehui, ZHANG Wannian, ZHOU Kun. Synthesis Process of 5-Methoxytryptamine[J]. Contemporary Chemical Industry, 2026, 55(4): 829-832.

1,2 ， 1,2 ， 1

(1. ， 113001;

2. 大连理工大学研究院， )

关键词：5-羟色胺；二碳酸二叔丁酯；碘甲烷；反应；催化剂

中图分类号：TQ423.11

文献标志码：A

文章编号：1671-0460（2026）04-0829-04

Synthesis Process of 5-Methoxytryptamine

XU Yuehui 1,2 , ZHANG Wannian 1,2 , ZHOU Kun 1

(1. School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun Liaoning 113001, China; 2. Ningbo Institute of Dalian University of Technology, Ningbo Zhejiang , China)

Abstract: The construction of methoxytryptamine was completed by using serotonin as reactant and methylomethane iodide as methylation reagent, and the methodology of the reaction was studied. The synthesis process of this compound is as follows: First, 5-hydroxytryptamine and di-tert-butyl dicarbonate react at room temperature to produce the Boc-protected 5-HT intermediate; then, under the action of potassium carbonate, this intermediate reacts with methyl iodide to obtain Boc protected 5-methyltryptamine; the Boc protecting group is then hydrolyzed with hydrochloric acid, followed by post-treatment to yield the target product with a yield of around 81%.

Keywords: Serotonin; Di-tert-butyl dicarbonate; Methyl iodide; Reaction; Catalyst

色胺因其独特的结构特性，在药物分子的全合成中被广泛应用于化学键的构建环节[1]。（剩余8254字）