4-甲氧基联苯的合成工艺

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引用格式：，等.4-甲氧基联苯的合成工艺[J].当代化工，2026,55（4）：825-828.

PENG Xin, YU Junwen, ZHANG Wannian, et al. Synthesis Process of 4-Methoxybiphenyl [J]. Contemporary Chemical Industry, 2026, 55 (4): 825-828.

1,2 ， 2,3 ， 1,2 ， 1

关键词：4-甲氧基碘苯；4-甲氧基联苯；联苯；苯；合成

中图分类号：TQ4211

文献标志码：A

文章编号：1671-0460（2026）04-0825-04

Synthesis Process of 4-Methoxybiphenyl

PENG Xin 1,2 , YU Junwen 2,3 , ZHANG Wannian 1,2 , BAO Huan 1

School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun Liaoning 113001, China;

Ningbo Institute of Dalian University of Technology, Ningbo Zhejiang 315016, China;

School of Material Science and Engineering, Shenyang University of Chemical Technology, Shenyang Liaoning 110142, China)

Abstract: The synthesis of 4-methoxybiphenyl was studied, using 4-methoxyiodobenzene and boronic acid pinacol ester as raw materials, the intermediate product 2-(4-methoxyphenyl)-4,4,5,1,3,2-dioxolane was synthesized, and then the intermediate reacted with iodobenzene to obtain the desired substance, which was analyzed by methodology. The optimal synthesis conditions for this compound were as follows: intermediates, iodobenzene, potassium acetate, and palladium diacetate were added in a sealed tube, and then methanol solvent was also added, the reaction was carried out under argon atmosphere at 80 °C for 3 h, and after post-treatment, 4-methoxybiphenyl was obtained in 83% yield.

Keywords: 4-Methoxyiodobenzene; 4-Methoxybiphenyl; Biphenyl; Benzene; Synthesis

联苯类化合物在日常生活中应用广泛，特别是在药物化学中经常被作为药物分子的骨架结构 [1-6] 。（剩余8882字）