糖尿病相关干眼病理机制的研究进展

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[中图分类号]R587 [文献标识码]A [文章编号]1672-4062（2026）02（a）-0185-05

Research Progress on the Pathological Mechanism of Diabetic-related Dry Eye

PIAOZhenying，CUI Jun，LU Yan，QUANYuzhu，CUI Renzhe， TIANLianji

DepartmentofOphthalmologyAfiliatedHospitalofYanbianUiversity，Yanji33Ooo，Jilin，Cia [Abstract] Dryeye is acommon ocular complication in patients with diabetes.The pathogenesis ofdiabetic dry eye is complex，including theefectsof high blood glucoseonthemicroenvironmentof theocularsurfaceand thestructure andfunctionofornealnerves，dysfunctionofthelacrimalgland，excesiveevaporationoftearsleading todcreased stabilityof thetearfilm，andocularsurfaceinflammation，allof whichareimportantfactorsinthepathogenesisof diabeticdry eye.The glucagon-like peptide-1receptor（GLP-1R）plays akey role inthe process of lacrimal gland injury andinflammatoryresponse，and inordertofindefectivetreatment methods fordiabeticdryeye，itis necessaryto focus on studying the formation and activation of theGLP-1R complex.Thisarticle discussesthe pathogenesis of diabeticdryeyefromthreeaspects：abnormalcornealperipheral nerves，decreased tearfilmstabilityandocularsurface inflammation，providing a reference for the preventionand treatment of diabetic dry eye in the future.

[Keywords] Diabetic-relateddryeye;Pathogenesis; Glucagon-likepeptide-1receptor; Tear film stability

糖尿病（diabetesmellitus，DM）是一类以持续性高血糖为特征的代谢性疾病，由胰岛素分泌障碍或作用障碍引起，可引起多种眼部疾病[1]。（剩余9521字）