高甘油三酯血症性急性胰腺炎合并糖尿病患者重症化的危险因素分析

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[中图分类号]R657.5 [文献标识码]A [文章编号]1672-4062（2026）02（a）-0018-04

Risk Factors for Severe Disease in Patients with Hypertriglyceridemic AcutePancreatitisComplicatedbyDiabetesMellitus

HE Zhizhong'，ZENG Zhiyang，ZHUANG Fulong

.DepartmentofGastroenterology，AfiliatedPeople's Hospitalof Quanzhou Medical College，Quanzhou362000，Fujian，China;2.Departmentof Internal Medicine，Chongwu Town Central Health Center，Hui'an County，Quanzhou 362100，Fujian，China;3.Departmentof Gastroenterology，Quanzhou Decheng Hospital，Quanzhou 36210o，Fujian， China

[Abstract]Objective To identifyrisk factors associated with progression to moderatelysevere acute pancreatitis and severeacute pancreatitis （MSAP/SAP）in patients with hypertriglyceridemic acute pancreatitis （HTG-AP）and diabetes mellitus （DM）.Methods A totalof65 patients with HTG-APcomplicated with DMadmitted to theAfliaed People's HospitalofQuanzhou Medical Colege from January 2022 to October 2O25 wereretrospectively selected.According to whether they progressed to MSAP/SAP，they were divided into severe group （3O cases） and non-severe group （35 cases）.The clinical dataof the two groups werecollectedandcompared.Binary Logistic multivariate regression analysis was used toanalyzethe independent risk factors for the severityof HTG-APpatients with DM.Results The severe group had higher body mass index （BMI），glycatedhemoglobinA1c （HbAlc），and C-reactive proteinat48 hoursafter admission （CRP-48 h） compared with the non-severe group，the differences were statistically significant（all P <0.05）. Binary Logistic multivariate regression analysis revealed that BMI≥28 kg/m2 （OR=3.338，95%CI： 1.203-9.259）， HbA1c≥7.0% （OR=2.875，95%Cl：1.107-7.463），and CRP-48 h≥150 mg/L（0R=5.996，95%CI： 2.038-17.241） were independent risk factors for progression to MSAP/SAP（all P<0.05 ）.Conclusion In patients with HTG-AP and DM， obesity，poorlong-termglycemiccontrol，andelevatedearlyinflammatorymarkersarekeyriskfactors fordisease progression to severe forms.Early recognition and targeted managementof these factors may improve clinical outcomes.

[Keywords] Hypertriglyceridemia; Acute pancreatitis; Diabetes melitus; Body massindex;Risk factors

急性胰腺炎（acutepancreatitis，AP）是临床常见的消化系统急症，病因多样。（剩余4887字）