3项胰岛自身抗体与生化指标联合检测在LADA早期诊断中的运用价值分析

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[中图分类号]R446.1 [文献标识码]A [文章编号]1672-4062（2026）02（a）-0051-0

ApplicationValue Analysisof Combined Detectionof Three Pancreatic Autoantibodies and Biochemical Indicators in Early Diagnosis of Patients withLADA

WANG Li

epartment of Laboratory，Panzhou People's Hospital，Liupanshui 5535O7，Guizhou，Chin：

[Abstract]Objective To investigate theapplication valueofcombined detectionofthree isletautoantibodiesand biochemicalindexes intheearlydiagnosis oflatentautoimmunediabetesmelitus inadults （LADA）.MethodsAtotalof 120 patientswith diabetes diagnosedand treatedin Panzhou People'sHospital fromJanuary 2O22 to December 2024 were conveniently selected and divided into type2 diabetes mellitus （T2DM） group n =60） and LADA group （ n =60）according to the typeof disease.The glutamicaciddecarboxylase antibodies（GADA），insulinautoantibodies （IAA），islet cell antibodies （ICA）and routine biochemical indexes [fasting plasma glucose （FPG），2-hour postprandial plasma glucose （2 hPG），glycated hemoglobinA1c （HbAlc），C-peptide] were detected andcompared between the two groups. Results The levels of IAA，ICA，GADA，FPG，2 hPG and HbAlc in the LADA group were higher than those in the T2DM group，and the levelof C-peptide was lower than that in the TDM group，the diferences were statisticall significant （all P<0.05 ）.The area under the curve of combined detection of each index was O.935，the sensitivity and specificity were 96.67% and 88.33% ，respectively，which were higher than those of single detection.Conclusion The detectionofbiochemicalindicatorsintheearlydiagnosisandidentificationofLADAcombinedwiththreeisletautoantibodiescanimprove thediagnostic eficiencyand has guiding significancefor clinical follw-up treatment decisions.

[KeyWords]Latentautoimmunediabetesmelitusinadults;Type2diabetes melitus;Isletautoantibodies;Blood glu cose; Glycated hemoglobin A1c

成人隐匿性自身免疫性糖尿病（latentautoimmunediabetesmellitusinadults，LADA）是一种特殊类型的糖尿病，发病机制与1型糖尿病（type1dia-betesmellitus，T1DM）相似，临床症状更接近2型糖尿病（type2diabetesmellitus，T2DM），但胰岛β细胞衰退速度远超T2DM，容易误诊或漏诊，不利于临床治疗]。（剩余4633字）