特布他林联合N-乙酰半胱氨酸治疗对老年慢阻肺患者 肺功能、动脉血气及运动耐力的影响

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中图分类号：R563 文献标识码：A文章编号： 1006-1959（2026）05-0148-04

DOI：10.3969/j.issn.1006-1959.2026.05.027

Effect of Terbutaline Combined with N-acetylcysteine on Pulmonary Function，Arterial Blood Gas and Exercise Tolerance in Elderly Patients with Chronic Obstructive Pulmonary Disease

DAI Xinyu1，ZHANG Jieshu²，LIU Cheng3 （DepartmentofGriatrics'，theThirdDepartmentofIntealMedicie，Departmentofehabilitation，WannianountyHospialf Traditional Chinese Medicine，Wannian 3355oo，Jiangxi， China）

Abstract：ObjectieTexploeetofterutalinB）omedihacetylysteie（NAC）inereatmentofderlyaitsi chronicobstructivepumoarisease（O）MetdsTtalllderlyatientsithOoeredmitoWaanCountysialf TraditionalChineseMdicinefroJauary2toJauayreeollditsdyesepatientseendomlyigdtoi control group（ n =30）oranobservationgroup（n=3O）usingarandomnumbertable，withthecontrolgroupreceivingTBLtherapy，whereasthe observationgrouwasreatedwithacombinationofTBLandNAC.TheinicalsymptomsCOPDAsessmentTest（CA）score，St.George's RespiratoryQutieoe]oacdialiy）daoi （FEV/FVC）]，arterial blood gas[arterial partial pressure of oxygen （ PaO2） ，arterial partial pressure of carbon dioxide （PaCO2）]，exercise tolerance were comparedbetweenthetwogroupsResultsIntragroupomparisonrevealedthataftertreatment，CAandSGRQsoresasellasPaCC ，2 level were significantlylower than those before treatmentvaluesinboth groups，whileFVC，FEVi/FVC，and PaO2 levels were significantly elevated （P<0.05）. Intergroupcomparisonfurteremonstratedtatheseimprovementsereoreprooncedinteseatiogoupsevidencedysiiicantly lower CATand SGRQ scores and PaCO 2 level，coupledwithsignificantly higherFVC，FEV/FVCrationd PaO2 level compared to the control group （ P< O.05）Patineaomosatedlaepoeticeadai group（

KeyWords：Chronic obstructivepulmonary disease;Terbutaline;N-acetylcysteine;Pulmonary function

慢阻肺（chronic obstructive pulmonary disease，COPD）为老年人常见呼吸内科疾病，伴气流受限、通气障碍等典型表现，可引发持续性肺功能损害，导致呼吸衰竭、死亡等严重后果，其临床治疗尤为重要[2]现如今，特布他林（terbutaline，TBL）与N-乙酰半胱氨酸（N-acetylcysteine，NAC）均为COPD常用治疗药，前者为短效 β2 受体激动剂（ β2 adrenoceptor ago-nists，SABA），可快速松弛气道平滑肌，促进支气管扩张，以缓解患者的呼吸道症状[34；后者则属于黏液溶解剂，可降低黏液黏稠度，促进气道分泌物的稀释与排出，进而改善患者呼吸道通气功能5。（剩余5441字）