维生素 B₆ 联合盐酸多西环素治疗玫瑰痤疮的临床效果 及对皮肤屏障的影响

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中图分类号：R758.734 文献标识码：A文章编号： 1006-1959（2026）05-0144-04

DOI：10.3969/j.issn.1006-1959.2026.05.026

Clinical Effectof Vitamin B6 Combined with Doxycycline Hyclate in the Treatment ofAcneRosaceaand itsEffecton SkinBarrier

LIU Junying

（Department ofDermatology，TianjinPort Hospital，Tianjin 30O456，China）

Abstract：Objective To evaluate the efficacy of vitamin B6 combined with doxycycline hyclate in the treatment of acne rosacea and its effect on skin barier.MetodsFroMay2toay24，82paietsithcerosaceaowereadmitedtoTanjnortHspitalwereselecedste researchjetsUsingtdomumbertableetd，tyeiedtotrolgoupndsudyoupit4patitschope control group received vitamin B6 ointment，while thestudy groupwasgivenadditional doxycycline hyclate.The symptomscores （telangiectasia， papules，lil area]，inflammatory factorlevels [serumsolubleinterleukin-2 receptor （sIL2R），tumor necrosis factor- ∇⋅α∝ （TNF -α ），feedinginhibitor1（Nesfatin-1）， Toliketooouoileodssulso hadthelwertoordevesoffaaoctostreotalieteftreantndee function than those of the control group （P6 combined with doxycycline hyclate is effective in the treatment of acne rosacea，wichielypoetrptosoteoeyfinercddcettoose

Keywords：Vitamin B6; Doxycycline hyclate;Acne rosacea;Skin barrier

玫瑰痤疮（acnerosacea）是一种慢性炎症性皮肤病，多发生于颜面部。（剩余5158字）