基于孟德尔随机化分析的肠道菌群和新生儿高胆红素血症因果关联研究

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中图分类号：R722.1 文献标识码：A文章编号：1006-1959（2026）05-0022-06

DOI：10.3969/j.issn.1006-1959.2026.05.004

Study on the Causal Relationship Between Intestinal Flora and Neonatal HyperbilirubinemiaBased on Mendelian Randomization Analysis

KONG Dejin，GAO Yang

（PediatricDepartmentofLinyiCentral Hospital，Linyi 2764OO，Shandong，China）

Abstract：ObetieTexplorethusaleltioshipetweenintestinalflorandneoatalhrbliubineiabyMendelianndoatio method.MethodsUsigtheummaydataoflargesamplegenomewideociationstudy（GWA），tegeneticlocioelyelatedtooatal hyperbilrubineiaereseletedasinstrumentalarablesTwosapleMendelianandomzatioaalysisaspeforedsingivesevance weightingddlaeas florandeoatalherblbieasultseivsearanceeightingetodsodtatfidobacte（OR091 0.813）dlleallbl MREggerregressonweightedeiansimpleodelandweightedodelwerecosistetwithoseofivesevaranceweightingethod ConclusionTereisnegativecausalrelatioshipetwenteabundanceofBifidobacteumandtheiskofneonatalhyperbiliubia.

Keywords：Intestinal flora;Neonatal hyperbilirubinemia;Mendelian randomization

新生儿高胆红素血症（neonatalhyperbilirubine-mia）是新生儿期的常见疾病，可见于约 60% 足月新生儿和 80% 早产儿，严重的高胆红素血症由于其神经毒性会遗留神经系统后遗症。（剩余7825字）