基于代谢组学探究原花青素改善酒精肝机制

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文献标识码：A

中图分类号：R285.5

文章编号：1006-1959（2026）05-0008-08

DOI：10.3969/j.issn.1006-1959.2026.05.002

Exploring the Mechanism of Procyanidin in Improving Alcoholic Liver Based on Metabolomics

WULihong，WANG Yuening，REN Liying，CHEN Zhigang （ClinicalPharmacy，FengrunDistrictPeople'sHospital，TangshanO64Ooo，Hebei，China）

Abstract：OectieTploeheargedularhasofprocdinBB）ineamentfoliciveae）d toprovidetoetlsifocalteetiofDetosLodelfcestablisdtragsrcdstof （204 40% alcoholsolutio（kgd.lrolou（o）olodlgouou）oitieoloo） highdosePB2goup（PBgroup）andlowdosePB2goup（BLgoup）weresetup，with6miceineachgroup.lanineaminotransferase（A）， aspartatetransferSrdG）ttalseabolieadkesinaed technologywasusedforplasmametaboloicsaalysis，ndKGGerichmentaalysisasusedtosrenthekeymetabolicpathayofB2 intervention.ResultsThedatashowedthatPB2couldsignificantlyreducethelevelsofALT，ASTandTGinALDmodelmice（ P<0.05 ）.Atthesame time，the markers related to alcohol metabolism were improved，thereby increasing the NAD +/ NADHratio.Metabolomicsanalysis showedthatPB2 couldimprovetheidmetabolsmsodercausedbDyegulatingmetabolicpathassuchasaohsdsterodooeiost ConclusionPB2cansignificantlyrducethelevelofiverenzyesinALDmice，mprovealcoolmetabolismmarkersndegulaterelated metabolicpathatpovidealsiualostteiDrovfa and development.

KeyWords：Procyanidin;Metabolomics;Alcoholicliverdamage;Lipidmetabolism

酒精性肝损伤（ALD）如同隐匿在杯中酒里的“肝脏杀手”，由过量饮酒引发的慢性肝损伤正悄然威胁着全球公共健康[1。（剩余10324字）