石斛消萎汤联合标准四联疗法治疗慢性萎缩性胃炎伴肠化生临床研究

打开文本图片集

中图分类号］R256.3 [文献标志码］A [文章编号]0257-358X（2026）02-0161-07

Abstract Objective：To explore the effects of ShihuXiaowei Decoction（石斛消萎汤）combinedwith standard quadruple therapyon intestinal’flora，oxidative stressand inflammatory factors in patients with chronicatrophic gastritis（CAG）complicatedwith gastric intestinal metaplasia（GIM）.Methods：A total of 11O CAG patients complicated with GIM were selected and randomlydivided into the western medicine group（treated with standard quadruple therapy）and the integrated traditional Chineseand western medicine group（treated with Shihu Xiaowei Decoction combined with standard quadruple therapy）according to therandom number tablemethod，with 55 cases ineach group.Theintestinal floraindexes，oxidative stressindexes，inflammatory factors，gastricfunction indexes， and gastric mucosal pathological scores before and after treatment were compared between the two groups. In addition，the clinical eficacy and incidence of adverse reactions were compared between the two groups. Results：After treatment，the levelsof Lactobacilus，，Bifidobacterium and superoxide dismutase（SOD）in bothgroups increasedsignificantly comparedwith those before treatment，and the levelsin the integrated traditional Chinese and western medicine group were higher than those in the western medicine group（ P< 0.05）.The levelsof Enterococcus，Enterobacter，nitricoxide（NO），and malondialdehyde（MDA）wereall lower than those before treatment，and the levels in the integrated traditional Chinese and western medicine group were lower than those in the western medicine group（ P<0.05 ）.After treatment，the levelsof interleukin- 6 （IL-6），Creactive protein（CRP），and tumor necrosis factor- α （TNF- α ）in both groups were lower than those before treatment，and the levels in the integrated traditional Chinese and western medicine group were lower than those in the western medicine group（P

慢性萎缩性胃炎（CAG）是一种临床常见消化系统疾病，好发于中年以上人群。（剩余8359字）