黄芪多糖对血管内皮细胞损伤的保护作用及机制研究进展

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【中图分类号】R285.6 【文献标志码】A 【文章编号】1007－8517（2026）06-0084-09

DOI： 10. 3969/j. issn. 1007 -8517. 2026. 06. zgmzmjyyzz202606017

Research Progress on theProtective Effect and Mechanismof Astragalus Polysaccharide on Vascular Endothelial Cell injury

WANG Yingting1，2 CHENYichun² WU Ruipeng' 2

Laboratoryof High Altitude HypoxiaEnvironmentandLife Healthof Xizang Minzu University，Xianyang712Ooo，China; 2.Joint Laboratory for Researchon Active Components and Pharmacological Mechanismof Zang Materia Medica of Zang Medical Research Center of Zang，School of Medicine，Xizang Minzu University， Xianyang 7120O，China

Abstract：Theoccurrnceofvariouscardiovasculardiseasesisbasedonvascularendothelialinjuryanddysfunction，andthe integrityofthestructueadfunctionofvascularendothelalcelsisucialfortepreventioofardiovasulardseas.Aragaluspolysaccharides（APS）isoneoftemainbioactivecompoentsofAstragalus.APScaniibitedothelialcellapoptosis，promoteedo thelialcellprolferationandangiogenesisAScanprotctagastvascularndotelialoxidativedamage.APSreducestheactivation of inflammation-elatedgenesandtheinflammatoryadhesionofvascularendothelialcels.APSregulatesvasomotorfactorpotection vascularendothelialinjurymaintainnoralphysiologicalfunctionofvasularendothelum.Thisarticlereviewstheprotectivehnismof APSonvascularendothelialinjury，inordertoprovidenewideasandbasisforthepreventionandtreatmentofcardiovascular disease.

KeyWords：Astragalus Polysaccharides；Endothelial Cells；Cardiovascular Diseases

多糖是单糖以 ∝ 或 β 糖苷键连接的高分子碳水化合物，一种单糖分子缩合而成的多糖称为均一性多糖，如糖原、淀粉等；两种以上的单糖分子缩合而成的多糖称为不均一性多糖，如透明质酸、硫酸软骨素等。（剩余18019字）