血清胃功能对幽门螺杆菌感染者胃黏膜萎缩程度的诊断价值

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中图分类号：R573

文献标识码：A

DOI：10.3969/j.issn.1006-1959.2026.09.018

文章编号：1006-1959（2026）09-0115-04

Diagnostic Value of Serum Gastric Function on the Degree of Gastric Mucosal Atrophy

in Patients with Helicobacter Pylori Infection

SHI Liangyu， GAO Dusi， WU Nanfei， GAO Yingxin， WU Changwen

（Department of Gastroenterology， the People's Hospital of Tongcheng， Tongcheng ， Anhui， China）

Abstract： Objective To investigate the diagnostic value of serum gastric function in the degree of gastric mucosal atrophy in patients with Helicobacter pylori infection. Methods A total of 121 patients who tested positive for Helicobacter pylori at Tongcheng People's Hospital from April 2023 to April 2024 were enrolled as study subjects. All patients underwent gastroscopy and serum gastric function testing. Based on their endoscopic gastric mucosal findings， patients were classified according to the Kimura-Takemoto classification and divided into three groups： C1-C2 group， C3-O1 group， and O2-O3 group. The serum levels of pepsinogen （PG） I， PG II， gastrin-17 （G-17）， and the pepsinogen ratio （PGR） were compared among the three groups. Results There were no statistically significant differences among the three groups in terms of age， sex， education level， place of residence， BMI， or history of alcohol consumption （P>0.05）. Statistically significant differences were observed among the three groups in serum gastric function markers， including PG I， PG II， G-17， and PGR （P<0.05）. Specifically， compared with the C1-C2 group， the C3-O1 and O2-O3 groups showed decreased PG I and PGR levels， and increased PG II and G-17 levels （P<0.05）. Compared with the C3-O1 group， the O2-O3 group showed decreased PG I and PGR levels， and increased G-17 levels （P<0.05）. Conclusion Serum gastric function reflects the changes of gastric mucosal function and state in patients with Helicobacter pylori infection through multiple dimensions. Its combined application can improve the diagnostic accuracy of gastric mucosal atrophy and provide a basis for risk stratification of gastric cancer.

Key words： Helicobacter pylori infection; Gastric function; Kimura-Takemoto classification; Chronic gastritis

胃癌（gastric cancer）在我国的发病率和死亡率均位居全球第3位[1]。（剩余5847字）