基于孟德尔随机化分析血液代谢物与脑出血的因果关系

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关键词：代谢产物;脑出血;孟德尔随机化;1-硬脂酰-2-花生四烯酰-gpc（18：0/20：4）;因果关系

文献标识码：A

DOI：10.3969/j.issn.1006-1959.2026.09.009

文章编号：1006-1959（2026）09-0061-05

Analysis of the Causal Relationship Between Blood Metabolites and Cerebral Hemorrhage

Based on Mendelian Randomization

QIN Lu 1 ， ZHAI Yang 2 ， PANG Xingwang 2 ， WANG Han 2 ， MO Zhizhen 2 ， XIAO Yuhan 2 ， LI Haina 2 ， CHI Tengfei 2

（1. Geriatrics Department of Guangxi International Zhuang Medical Hospital， Nanning 530201， Guangxi， China;

Medical Department， the Seventh People's Hospital of Nanning City， Nanning 530001， Guangxi， China）

Abstract： Objective To explore the causal relationship between serum metabolites and intracerebral hemorrhage （ICH） by two-sample bidirectional Mendelian randomization （MR） analysis. Methods Genome-wide association study （GWAS） data of cerebral hemorrhage were obtained from public databases. A published GWAS containing 1400 metabolites was used as the exposure factor， and SNPs significantly related to the exposure factor were selected as the instrumental variable （IV）. R software was used to analyze the causal relationship between serum metabolites and cerebral hemorrhage. The methods used include inverse variance weighting （IVW）， MR–Eggeer regression and simple model method. The data results were analyzed such as heterogeneity， pleiotropy， sensitivity， etc. to verify the reliability of the results. The results were verified by reverse MR analysis. Results Metabolite "1-stearoyl-2-arachidonic acid-gpc （18：0/20：4）" （IVW： OR=0.888， 95% CI： 0.830–0.950， P<0.001） was negatively correlated with cerebral hemorrhage. Conclusion 1-Stearoyl-2-arachidonic acid-gpc （18：0/20：4） is a protective factor for cerebral hemorrhage. With the increase of this metabolite， the risk of cerebral hemorrhage decreases. This may provide a new reference for the pathogenesis， early prevention， clinical treatment and scientific research of cerebral hemorrhage.

Key words： Metabolites; Cerebral hemorrhage; Mendel randomization; 1-Stearoyl-2-arachidonic acid-gpc（18：0/20：4）; Causal relationship

脑出血（ICH）是指原发性非创伤性脑实质内出血，导致脑实质内血液积聚的一种严重的神经系统疾病[1]。（剩余7472字）