沙门菌耐药基因水平转移机制及影响因素

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中图分类号：S852.612 文献标志码：A 文章编号：0366-6964（2026）01-0108-12

Abstract： Salmonell is a common foodborne pathogen worldwide. With the promotion and use of antibiotics，more and more Salmonella produce or acquire antibiotic resistance genes （ARG） through vertical transmission and horizontal gene transfer （HGT），causing widespread dissemination of antibiotic resistance. In the process of horizontal gene transfer，ARGs are mainly carred by mobile genetic elements （MGEs），which are important mediators of HGT and can facilitate the spread of ARGs. Among them，MGEs mainly include plasmids， integrons and conjugative elements， transposons， insertion sequences，and phages，etc. MGE-associated transfer mechanisms，accessory gene compositions，and relationships between ARG dissemination and animal sources and geographic environments vary. The aim of this review is to outline the HGT mechanism of ARG in Salmonella， the different MGE-mediated HGT mechanisms and the influencing factors of HGT occurrence and development，which is of great significance for the in-depth investigation of the HGT mechanism of drug resistance in Salmonella.

Keywords： Salmonella; horizontal gene transfer; antibiotic resistance gene;mobile genetic element Corresponding author： ZUO Runan， E-mail： zrn91O314@ahau. edu. cn

1沙门菌耐药性

沙门菌是常见的人类和动物病原体，可导致多种疾病，包括肠胃炎和败血症等，严重时可致死亡[1]。（剩余32965字）