m6A修饰调控miRNAs影响细胞能量代谢的研究进展
打开文本图片集
中图分类号：S852.21 文献标志码：A 文章编号：0366-6964（2026）01-0080-16
Abstract：N6-methyladenosine （ m6A ）modification and microRNAs （miRNAs） are important factors in gene expression regulation，playing a crucial role in cellular energy metabolism. m6A （20 modification participates in various physiological and pathological processes by regulating RNA stability，splicing and translation. miRNAs，as a class of small molecule RNAs，directly affect celllar metabolic pathways by targeting and regulating gene expression. The m6A modificationmediated regulation of miRNAs plays a pivotal role in cellular energy metabolism，especially in regulating metabolic processes such as glycolysis and mitochondrial function. By discussing the regulatory effect of m6A modification on miRNAs and its impact on energy metabolism，this review elaborating in detail on the mechanism by which m6A modification affects cellular energy metabolism by regulating miRNAs，and reveals the possibility of m6A modified miRNAs as targets for regulating cellular energy metabolism，in order to provide a theoretical reference for regulating animal growth and development and treating energy metabolism-related diseases.
Keywords： m6A modification;miRNAs；energy metabolism；mitochondriε ∗ Corresponding author：ZHANG Jiaojiao，E-mail： zhangjjff@126.com
m6A 修饰是指信使RNAs（messenger RNAs，mRNAs）或非编码RNA的腺嘌呤上第6位氮原子的甲基化，广泛存在于多种RNA分子中，包括mRNAs、转运RNAs（transferRNAs，tRNAs）、核糖体RNAs（ribosomal RNAs，rRNAs）、环状RNAs（circularRNAs，circRNAs）miRNAs和长链非编码RNAs（long non-codingRNAs，lncRNAs），并常见于终止密码子和 3′ 非翻译区（ 3′ untranslated region，3′UTR 附近的RRACH R=G/A H=U/A/C 序列[1-4]。（剩余36643字）
