家畜单细胞转录组学数据库的研究现状与展望

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中图分类号：S813 文献标志码：A 文章编号：0366-6964（2026）01-0001-12

Abstract：This article aims to elucidate how single-cell omics technologies advance livestock research and provides a systematic review of the construction process， current applications，and major challenges of single-cel transcriptomic databases in domestic animals. It seeks to offer data references and analytical frameworks for researchers，thereby promoting deeper application of this technology in livestock studies. This review conducted a comprehensive review and integrated analysis of existing single-cell transcriptomic database resourcesfor livestock， summarizing their construction methodologies and application pathways，while also discussing current technical bottlenecks. The review demonstrates that single-cell transcriptomics offers novel perspectives and abundant data resources for elucidating mechanisms of livestock diseases，molecular breeding，and health management，while also revealing significant challenges in areas such as data integration and annotation standardization. Future efforts should focus on constructing high-quality databases， developing analysis algorithms tailored to livestock species，and promoting multi-omics integration to fully leverage the potential of single-cell technologies in the development of animal husbandry.

Keywords：livestock;single-cell transcriptomics;database * Corresponding authors：LI Yuanfang，E-mail：yuanfanglil99l@163.com；LIU Qiaoming，Email：cslqm@henu.edu.cn

单细胞转录组学测序技术（scRNA-seq）通过解析复杂组织中单个细胞的转录组信息，揭示了组织中的细胞异质性和细胞间的相互作用，为生命科学研究提供了前所未有的深度和精度[1]。（剩余22842字）