色氨酸代谢产物调控肠道氧化应激研究进展

打开文本图片集

中图分类号：S852.2 文献标志码：A 文章编号：0366-6964（2026）01-0046-12

Abstract： The gastrointestinal tract is not only a place where nutrients digest， absorb and metabolize， but also serves as both a primary source and a major target of reactive oxygen species （ROS）. Intestinal health is a cornerstone of animal growth and a critical determinant of livestock production efficiency. Tryptophan，an essential amino acid，is metabolized by both host cels and gut microbiota into various bioactive compounds， such as indole，kynurenine and 5-hydroxytryptamine. These metabolites act as endogenous ligands to regulate intestinal oxidative stress and inflammatory damage. This review summarizes the host and microbial pathways of intestinal tryptophan metabolism， explores the physiological functions of tryptophan metabolites in modulating oxidative stress and tissue repair，and discusses the role of microbial tryptophan metabolism in potential nutritional interventions， including probiotics and nutritional supplements. These findings aim to inform research on nutritional strategies for managing gut health.

Keywords： intestine； oxidative stress; tryptophan metabolism; intestinal microorganisms; nutritional regulation

∗ Corresponding author： WANG Jing，E-mail： jingwangO23@hunau. edu. cn

在正常生理状态下，畜禽机体内具备完善的抗氧化系统，能够及时清除细胞中的活性氧自由基（reactiveoxygenspecies，ROS），维持细胞处于ROS的动态平衡。（剩余24991字）