冠状病毒辅助蛋白功能研究进展

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中图分类号：S852.659.6 文献标志码：A 文章编号：0366-6964（2026）01-0096-12

Abstract： The RNA genome of coronavirus contains multiple open reading frames，coding for structural proteins， non-structural proteins，as wellas accessory proteins. The accessory proteins of coronavirus are species specific，and the amounts of accessory proteins differ between the species. Coronavirus accessory proteins are not necessary for viral replication，but some of them are involved in the host immune response，viral pathogenesis and virus virulence. Research on coronavirus accessory proteins will provide new potential targets for the development of therapeutic drugs and theoretical guidance for disease prevention and treatment. In this paper， the functions of several representative accessory proteins of coronaviruses are reviewed. It focuses on the relationship between accessory proteins and virus-host interactions，including the role of accessory proteins in promoting host cell apoptosis，host innate immune regulation，and pathogenicity in the host. This will help to investigate the infection and pathogenesis of coronavirus，and provide reference for developing new vaccines and antiviral drugs.

Keywords： coronavirus;； accessory protein;cell apoptosis ； innate immunity； pathogenicity; vaccine∗ Corresponding author： JIANG Yi，E-mail： yijiang62O@126.com

冠状病毒（coronavirus，CoV）在分类上属于套式病毒目、冠状病毒科、冠状病毒属。（剩余23893字）